Scientists

Associate Professor

Yasutaka Motomura

Division of immunology and allergy Immunobiology
Allergy and Immunopathology

Research theme

  • Unraveling the pathophysiology of type 2 immune diseases
  • Decoding the mechanisms of allergy constitution and creating preventive strategies
  • Comprehensive understanding of the pre-disease state that transitions into immune diseases
Labo's Website

Selected publications;

  1. Otaki, N., Motomura, Y., Terooatea, T., Thomas Kelly, S., Mochizuki, M., Takeno, N., Koyasu, S., Tamamitsu, M., Sugihara, F., Kikuta, J., Kitamura, H., Shiraishi, Y., Miyanohara, J., Nagano, Y., Saita, Y., Ogura, T., Asano, K., Minoda, A., Moro, K. Activation of ILC2s through constitutive IFNγ signaling reduction leads to spontaneous pulmonary fibrosis. Nature communications 14, 8120, (2023)
  2. Tanaka, Y., Yamagishi, M., Motomura, Y., Kamatani, T., Oguchi, Y., Suzuki, N., Kiniwa, T., Kabata, H., Irie, M., Tsunoda, T., Miya, F., Goda, K., Ohara, O., Funatsu, T., Fukunaga, K., Moro, K., Uemura, S., Shirasaki, Y. Time-dependent cell-state selection identifies transiently expressed genes regulating ILC2 activation. Communications biology 6, 915, (2023)
  3. Imanishi, T., Unno, M., Yoneda, N., Motomura, Y., Mochizuki, M., Sasaki, T., Pasparakis, M., and Saito, T. RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8. Science advances 9, eadd6097, (2023)
  4. Kabata, H., Motomura, Y., Kiniwa, T., Kobayashi, T., Moro, K. ILCs and Allergy. Advances in Experimental Medicine and Biology 1365: 75-95, (2022)
  5. Naito M., Nakanishi., Y, Motomura, Y., Takamatsu, H., Koyama, S., Nishide, M., Naito, Y., Izumi, M., Mizuno, Y., Yamaguchi, Y., Nojima, S., Okuzaki, D., Kumanogoh, Semaphorin 6D-expressing mesenchymal cells regulate IL-10 production by ILC2s in the lung. Life Sci Alliance 5(11):e202201486, (2022)
  6. Hikichi, Y., Motomura, Y♯., Takeuchi, O., Moro, K♯. Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin. J Exp Med 218, (2021) ♯同等責任著者
  7. Momiuchi, Y＊., Motomura, Y＊., Suga, E., Mizuno, H., Kikuta, J., Morimoto, A., Mochizuki, M., Otaki, N., Ishii, M., Moro, K. Group 2 innate lymphoid cells in bone marrow regulate osteoclastogenesis in a reciprocal manner via RANKL, GM-CSF and IL-13. International Immunoogyl 33: 573-85, (2021) ＊同等筆頭著者
  8. Matsuyama, T., Machida, K., Motomura, Y., Takagi, K., Doutake, Y., Tanoue-Hamu, A., Kondo, K., Mizuno, K., Moro, K., and Inoue, H. Long-acting muscarinic antagonist regulates group 2 innate lymphoid cell-dependent airway eosinophilic inflammation. Allergy 76(9):2785-2796, (2021)
  9. Sudo, T., Motomura, Y., Okuzaki, D., Hasegawa, T., Yokota, T., Kikuta, J., Ao, T., Mizuno, H., Matsui, T., Motooka, D., Yoshizawa, R., Nagasawa, T., Kanakura, Y., Moro, K., and Ishii, M. Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. The Journal of experimental medicine 218, (2021)
  10. Satoh-Takayama, N., Kato, T., Motomura, Y., Kageyama, T., Taguchi-Atarashi, N., Kinoshita-Daitoku, R., Kuroda, E., Di Santo, J.P., Mimuro, H., Moro, K., and Ohno, H. Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA. Immunity 52, 635-649.e634, (2020)
  11. Miyajima, Y., Ealey, K.N., Motomura, Y., Mochizuki, M., Takeno, N., Yanagita, M., Economides, A.N., Nakayama, M., Koseki, H., and Moro, K. Effects of BMP7 produced by group 2 innate lymphoid cells on adipogenesis. International immunology 32, 407-419, (2020)
  12. Jiang, X., Kumar, A., Motomura, Y., Liu, T., Zhou, Y., Moro, K., Zhang, K.Y.J., and Yang, Q. A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. Journal of Medicinal Chemistry 63, 987-1001, (2020)
  13. Motomura, Y., Kobayashi, T., and Moro, K. The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells. Immunity 51, 598-600, (2019)
  14. Xu, W., Domingues, R.G., Fonseca-Pereira, D., Ferreira, M., Ribeiro, H., Lopez-Lastra, S., Motomura, Y., Moreira-Santos, L., Bihl, F., Braud, V., Kee, B., Brady, H., Coles, MC., Vosshenrich, C., Kubo, M., Di Santo, JP., and Veiga-Fernandes. NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors. Cell Reports 10, 2043-2054, (2015)
  15. Motomura, Y., Morita, H., Moro, K., Nakae, S., Artis, D., Endo, T.A., Kuroki, Y., Ohara, O., Koyasu, S., and Kubo, M. Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. Immunity 40, 758-771, (2014)
  16. Furusawa, J., Moro, K., Motomura, Y., Okamoto, K., Zhu, J., Takayanagi, H., Kubo, M., and Koyasu, S. Critical role of p38 and GATA3 in natural helper cell function. Journal of immunology 191, 1818-1826, (2013)
  17. Kubo, M., and Motomura, Y. Transcriptional regulation of the anti-inflammatory cytokine IL-10 in acquired immune cells. Frontiers in immunology 3, 275, (2012)
  18. Harada, Y., Tanaka, S., Motomura, Y., Harada, Y., Ohno, S., Ohno, S., Yanagi, Y., Inoue, H., and Kubo, M. The 3′ enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells. Immunity 36, 188-200, (2012)
  19. Motomura, Y., Kitamura, H., Hijikata, A., Matsunaga, Y., Matsumoto, K., Inoue, H., Atarashi, K., Hori, S., Watarai, H., Zhu, J., Taniguchi, M., and Kubo, M.The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nature Immunology 12, 450-459, (2011)
  20. Tanaka, S＊., Motomura, Y＊., Suzuki, Y., Yagi, R., Inoue, H., Miyatake, S., and Kubo, M. The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nature Immunology 12, 77-85, (2011) ＊同等筆頭著者
List back