Scientists

Professor

Hiroyuki Koike

Division of Cell Fate Regulation
Organoid
Labo's Website

Selected publications

代表的な業績　*:corresponding author, #:equal contribution

  1. Koike H*, Sugimura M, Ouchi R, Yoshimoto Y, Manabe I, Oishi Y*. Macrophage subpopulation promotes skeletal muscle regeneration through HGF/MET signaling-mediated skeletal muscle stem cell proliferation. Aging Cell. 24 (6): e70042. 2025. https://doi.org/10.1111/acel.70042
  2. Honda A, Koike H, Dohi T, Toyohara E, Hayakawa S, Tobe K, Manabe I, Ogawa R, Oishi Y*. CD206+ macrophages facilitate wound healing through interactions with Gpnmbhi EMBO Rep. 26 (14): pp.3679-3704. 2025. https://doi.org/10.1038/s44319-025-00496-4
  3. Oishi Y*,#, Koike H# (#:co-first authors), Kumagami N, Nakagawa Y, Araki M, Taketomi Y, Miki Y, Matsuda S, Kim H, Matsuzaka T, Ozawa H, Shimano H, Murakami M, Manabe I. Macrophage SREBP1 regulates skeletal muscle regeneration. Immunol. 14: 1251784. 2024. https://doi.org/10.3389/fimmu.2023.1251784
  4. Otomo K, Omura T, Nozawa Y, Edwards SJ, Sato Y, Saito Y, Yagishita S, Uchida H, Watakabe Y, Naitou K, Yanai R, Sahara N, Takagi S, Katayama R, Iwata Y, Shiokawa T, Hayakawa Y, Otsuka K, Watanabe-Takano H, Haneda Y, Fukuhara S, Fujiwara M, Nii T, Meno C, Takeshita N, Yashiro K, Rosales Rocabado JM, Kaku M, Yamada T, Oishi Y, Koike H, Cheng Y, Sekine K, Koga JI, Sugiyama K, Kimura K, Karube F, Kim H, Manabe I, Nemoto T, Tainaka K, Hamada A, Brismar H, Susaki EA*. descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques. Commun. 15 (1): 4941. 2024. https://doi.org/10.1038/s41467-024-49131-1
  5. Ouchi R*, Koike H*. Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids. Cell Dev. Biol. 11: 1133534 , 2023. https://doi.org/10.3389/fcell.2023.1133534
  6. Koike H, Manabe I, Oishi Y*. Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration. Regen. 42 (1): 48, 2022. https://doi.org/10.1186/s41232-022-00234-6
  7. Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, Nishii S, Thompson WL, Takebe T*, Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells. Protoc. 16 (2): pp.919-936, 2021. https://doi.org/10.1038/s41596-020-00441-w
  8. Liu L, Koike H, Ono T, Hayashi S, Kudo F, Kaneda A, Kagechika H, Manabe I, Nakashima T, Oishi Y*. Identification of a novel KLF5-dependent program and drug development for skeletal muscle atrophy. Natl. Acad. Sci. U.S.A. 118 (35): e2102895118, 2021. https://doi.org/10.1073/pnas.2102895118
  9. Shinozawa T, Kimura M, Cai Y, Saiki N, Yoneyama Y, Ouchi R, Koike H, Maezawa M, Zhang RR, Dunn A, Ferguson A, Togo S, Lewis K, Thompson W, Asai A, Takebe T*, High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids. Gastroenterology. 160 (3): pp.831-846, 2021. https://doi.org/10.1053/j.gastro.2020.10.002
  10. Han L#, Chaturvedi P#, Kishimoto K#, Koike H# (#:co-first authors), Nasr T, Iwasawa K, Giesbrecht K, Witcher PC, Eicher A, Haines L, Lee Y, Shannon JM, Morimoto M, Wells JM, Takebe T, Zorn AM*, Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Commun. 11 (1): 4158, 2020. https://doi.org/10.1038/s41467-020-17968-x
  11. Koike H, Iwasawa K, Ouchi R, Maezawa M, Giesbrecht K, Saiki N, Ferguson A, Kimura M, Thompson WL, Wells JM, Zorn AM, Takebe T*, Modeling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary, Nature, 574 (7776): pp.112-116, 2019. https://doi.org/10.1038/s41586-019-1598-0
  12. Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T*. Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell Metab. 30 (2): pp.374-384, 2019. https://doi.org/10.1016/j.cmet.2019.05.007
  13. Koike H, Zhang RR, Ueno Y, Sekine K, Zheng YW, Takebe T*, Taniguchi H*. Nutritional modulation of mouse and human liver bud growth through a branched-amino acid metabolism. Development. 144 (6): pp.1018-1024, 2017. https://doi.org/10.1242/dev.143032
  14. Koike H, Takebe T*, Generating Mini-Organs in Culture, Pathobiol. Rep. 4 (2): pp.59-68, 2016 https://doi.org/10.1007/s40139-016-0101-y
  15. Takebe T*, Enomura M, Yoshizawa E, Kimura M, Koike H, Ueno Y, Matsuzaki T, Yamazaki T, Toyohara T, Osafune K, Nakauchi H, Yoshikawa HY*, Taniguchi H. Vascularized and complex organ buds from diverse tissues via mesenchymal cell-driven condensation. Cell Stem Cell. 16 (5): pp.556-565, 2015. https://doi.org/10.1016/j.stem.2015.03.004
  16. Koike H, Ueno Y, Naito T, Shiina T, Nakata S, Ouchi R, Obana Y, Sekine K, Zheng YW, Takebe T, Isono K, Koseki H, Taniguchi H*, Ring1B Promotes Hepatic Stem/Progenitor Cell Expansion by Simultaneous Repression of Cdkn1a and Cdkn2a, Hepatology. 60 (1): pp.323-333, 2014. https://doi.org/10.1002/hep.27046
  17. Koike H, Ouchi R, Ueno Y, Nakata S, Obana Y, Sekine K, Zheng YW, Takebe T, Isono K, Koseki H, Taniguchi H*. Polycomb group protein Ezh2 regulates hepatic progenitor cell proliferation and differentiation in murine embryonic liver. PLoS One. 9 (8): e104776. 2014. https://doi.org/10.1371/journal.pone.0104776
  18. Takebe T*, Zhang RR#, Koike H# (#:co-second authors), Kimura M, Yoshizawa E, Enomura M, Sekine K, Taniguchi H*, Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Protoc. 9 (2): pp.396-409. 2014. https://doi.org/10.1038/nprot.2014.020
  19. Takebe T*, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, Zhang RR, Ueno Y, Zheng YW, Koike N, Aoyama S, Adachi Y, Taniguchi H*. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 499 (7459): pp.481-484, 2013. https://doi.org/10.1038/nature12271
  20. Koike H, Kubota K, Sekine K, Takebe T, Ouchi R, Zheng YW, Ueno Y, Tanigawa N, Taniguchi H*, Establishment of automated culture system for murine induced pluripotent stem cells. BMC biotechnol., 12: 81, 2012. https://doi.org/10.1186/1472-6750-12-81
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