Scientists

Professor

Tomokatsu Ikawa

Division of immunology and allergy
Immunobiology

Research theme

  • Differentiation program of hematopoietic stem cells toward T or B cells
  • Transcriptional, epigenetic and metabolic regulation of lymphocyte development
  • Pathogenic mechanisms of hematopoietic tumor onset
  • Development of a novel immune cell therapy using iLS cells
Labo's Website

Selected publications:

  1. Li S, Liu J, Min Q, Ikawa T, Yasuda S, Yang Y, Wang YQ, Tsubata T, Zhao Y, Wang JY. Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development. Int Immunol. (2018) In press
  2. Miyai T, Takano J, Endo TA, Kawakami E, Agata Y, Motomura Y, Kubo M, Kashima Y, Suzuki Y, Kawamoto H, Ikawa T. Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells. Genes Dev. 32:112-126, (2018)
  3. Ikawa T, Masuda K, Endo TA, Endo M, Isono K, Koseki Y, Nakagawa R, Kometani K, Takano J, Agata Y, Katsura Y, Kurosaki T, Vidal M, Koseki H, Kawamoto H. Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program. Genes Dev. 30: 2475-2485, (2016)
  4. Calés C, Pavón L, Starowicz K, Pérez C, Bravo M, Ikawa T, Koseki H, Vidal M. Role of Polycomb RYBP in maintaining the B-1 to B-2 B-cell lineage switch in adult hematopoiesis. Mol Cell Biol. 36:900-912, (2015)
  5. Ikawa T, Masuda K, Huijskens MJAJ, Satoh R, Kakugawa K, Agata Y, Miyai T, Germeraad WTV, Katsura Y, Kawamoto H. Induced developmental arrest of early hematopoietic progenitors leads to the generation of leukocyte stem cells. Stem Cell Reports. 5:716-727, (2015)
  6. Inoue T, Morita M, Hijikata A, Fukuda-Yuzawa Y, Adachi S, Isono K, Ikawa T, Kawamoto H, Koseki H, Natsume T, Fukao T, Ohara O, Yamamoto T, Kurosaki T. CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability. J Exp Med. 212:1465-1479, (2015)
  7. Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drabløs F, …, Ikawa T (36 out of 109), … ; FANTOM Consortium, Hume DA, Forrest AR, Sandelin A, Carninci P, Hayashizaki Y. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. 347:1010-1014, (2015)
  8. Ikawa T. Genetic and epigenetic control of early lymphocyte development. Curr Top Microbiol Immunol. 381:1-20, (2014)
  9. Itoh-Nakadai A, Hikota R, Muto A, Kometani K, Watanabe-Matsui M, Sato Y, Kobayashi M, Nakamura A, Miura Y, Yano Y, Tashiro S, Sun J, Ikawa T, Ochiai K, Kurosaki T, Igarashi K. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program. Nat Immunol. 12:1171-1180, (2014)
  10. Miyai T, Hojyo S, Ikawa T, Kawamura M, Irié T, Ogura H, Hijikata A, Bin BH, Yasuda T, Kitamura H, Nakayama M, Ohara O, Yoshida H, Koseki H, Mishima K, Fukada T. Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proc Natl Acad Sci U S A. 111(32):11780-5, (2014)
  11. FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, … , Ikawa T (102 out of 261), … , Carninci P, Hayashizaki Y. A promoter-level mammalian expression atlas. Nature. 507: 462-470, (2014)
  12. Ikawa T. Genetic and epigenetic control of early lymphocyte development. Curr Top Microbiol Immunol. 381:1-20, 2014
  13. Okuyama K, Ikawa T, Gentner B, Hozumi K, Harnprasopwat R, Lu J, Yamashita R, Ha D, Toyoshima T, Chanda B, Kawamata T, Yokoyama K, Wang S, Ando K, Lodish HF, Tojo A, Kawamoto H, Kotani A. MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcription factors. Proc Natl Acad Sci USA. 110: 13410-13415, (2013)
  14. Ikawa T, Hirose S, Masuda K, Kakugawa K, Satoh R, Shibano-Satoh A, Kominami R,Katsura Y, and Kawamoto H. An essential developmental checkpoint for production of the T cell lineage. Science 329: 93-96, 2010
  15. Ikawa T, Kawamoto H, Goldrath AW., and Murre C. E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J. Exp. Med. 203: 1329-1342, 2006
  16. Ikawa T, Kawamoto H, Wright LYT, and Murre C. Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity 20: 349-360, 2004
  17. Ikawa T, Masuda K, Min L, Minato N, Katsura Y, and Kawamoto H*. Identification of the earliest prethymic T-cell progenitors in murine fetal blood. Blood 103: 530-537, 2004
  18. Ikawa T, Fujimoto S, Kawamoto H, Katsura Y, and Yokota Y. Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2. Proc Natl Acad Sci USA. 98: 5164-5169, 2001
  19. Kawamoto H, Ikawa T, Ohmura K, Fujimoto S, and Katsura Y. T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver. Immunity 12: 441-450, 2000
  20. Ikawa T, Kawamoto H, Fujimoto S, and Katsura Y. Commitment of T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thumus revealed by a single progenitor assay. J. Exp. Med. 190: 1617-1625, 1999
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