Daisuke Kitamura

Devision of Cancer Cell Biology
Molecular Immunology

Research theme

  • Mechanisms of differentiation and maintenance of memory B cells and LLPCs.
  • Mechanisms regulating somatic hypermutation and selection of germinal center B cells.
  • Mechanisms regulating the fate of IgE+ B cells.
  • Mechanisms of the development and function of regulatory B cells.
  • Mechanisms of B cell receptor signal transduction.
  • Development of in vitro systems to select antigen-specific B cells.
  • Development of a new anti-tumor therapy using autologous plasma cells.

Selected publications:

  1. Kodama, T., Hasegawa, M., Sakamoto, Y., Haniuda, K. and Kitamura, D. Ubiquitination of IgG1 cytoplasmic tail modulates B cell signaling and activation. Int. Immunol. 2020. In press.
  2. Koike, T., Harada, K., Horiuchi, S. and Kitamura, D. The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets. eLife 8: e44245, 2019.
  3. Litzler, L.C., Zahn, A., Meli, A.P., Hébert, S., Patenaude, A., Methot, S.P., Sprumont, A., Bois, T., Kitamura, D., Costantino, S., King, I.L., Kleinman, C.L., Richard, S. and Di Noia, J.M. PRMT5 is essential for B cell development and germinal center dynamics. Nat. Commun. 10: 22, 2019.
  4. Takatsuka, S., Yamada, H., Haniuda, K., Saruwatari, H., Ichihashi, M., Renauld, J.-C. and Kitamura, D. IL-9 receptor signaling in memory B cells regulates humoral recall responses. Nat. Immunol. 19: 1025-1034, 2018.
  5. Le Gallou, S., Zhou, Z., Thai, L.H., Fritzen, R., de Los Aires, A.V., Mégret, J., Yu, P., Kitamura, D., Bille, E., Tros, F., Nassif, X., Charbit, A., Weller, S., Weill, J.C. and Reynaud, C.A. A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses. J. Exp. Med. 215: 2035-2053, 2018.
  6. Li, X., Gadzinsky, A., Gong, L., Tong, H., Calderon, V., Li, Y., Kitamura, D., Klein, U., Langdon, W.Y., Hou, F., Zou, Y.R. and Gu, H. Cbl ubiquitin ligases control B cell exit from the germinal-center reaction. Immunity 48: 530-541, 2018.
  7. Jiménez-Alcázar, M., Rangaswamy, C., Panda, R., Bitterling, J., Simsek, Y.J., Long, A.T., Bilyy, R., Krenn,V., Renné, C., Renné, T., Kluge, S., Panzer, U. Mizuta, R., Mannherz, H.G., Kitamura, D., Herrmann, M., Napirei, M. and Fuchs, T.A. Host DNases prevent vascular occlusion by neutrophil extracellular traps. Science 358: 1202-1206, 2017.
  8. Haniuda, K., Fukao, S., Kodama, T., Hasegawa, H. and Kitamura, D. Autonomous membrane IgE signaling prevents IgE-memory formation. Nature Immunol. 17: 1109-1117, 2016.
  9. Domeier, P.P., Chodisetti, S.B., Soni, C., Schell, S.L., Elias, M.J., Wong, E.B., Cooper, T.K., Kitamura, D. and Rahman, Z.S. IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J. Exp. Med. 213: 715-732, 2016.
  10. Kuraoka, M., Schmidt, A.G., Nojima, T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S.C., Kepler, T.B. and Kelsoe, G. Complex antigens drive permissive clonal selection in germinal centers. Immunity 44: 542-552, 2016.
  11. Fukao, S., Haniuda, K., Nojima, T., Takai, T. and Kitamura, D. Gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells. J. Immunol. 193: 635-644, 2014.
  12. Moutai, T., Yamana, H., Nojima, T. and Kitamura, D. A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. PLoS One 9 (3): e92732, 2014.
  13. Nojima, T., Haniuda, K., Moutai, T., Matsudaira, M., Mizokawa, S., Shiratori, I., Azuma, T. and Kitamura, D. In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo. Nature Commun, 2:465, 2011.
  14. Haniuda, K., Nojima, T., Ohyama, K. and Kitamura, D. Tolerance induction of IgG+ memory B cells by T-cell independent type II antigens. J. Immunol. 186: 5620-5628, 2011.
  15. Nakayama, J., Yamamoto, M., Hayashi, K., Satoh, H., Bundo, K., Kubo, M., Goitsuka, R., Farrar, M. A. and Kitamura D. BLNK suppresses pre-B cell leukemogenesis through inhibition of JAK3. Blood 113: 1483-1492, 2009.
  16. Yamamoto, M., Hayashi, K., Nojima, T., Matsuzaki, Y., Kawano, Y., Karasuyama, H., Goitsuka, R. and Kitamura, D. BASH – novel PKC – Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement. Blood 108: 2703-2711, 2006.
  17. Hayashi, K., Yamamoto, M., Nojima, T., Goitsuka, R. and Kitamura, D. Distinct signaling requirements for D selection, IgH allelic exclusion, pre-B cell transition and tumor suppression in B-cell progenitors. Immunity 18: 825-836, 2003.
  18. Tsuji, S., Okamoto, M., Yamada, K., Okamoto, N., Goitsuka, R., Arnold, R., Kiefer, F. and Kitamura, D. B cell adaptor containing Src Homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase1. J. Exp. Med. 194: 529-539. 2001.
  19. Hayashi, K., Nittono, R., Okamoto, N., Tsuji, S., Hara, Y., Goitsuka, R. and Kitamura, D. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells. Proc. Natl. Acad. Sci. USA, 97:2755-2760, 2000.