Scientists

Associate Professor

Shunsuke Kon

Devision of Cancer Cell Biology
Tumor biology

Research theme

  • Cell competition between normal epithelial cells and transformed cells
  • Interaction between cancer cells and normal stromal cells
  • Tumor-induced lymphangiogenesis
  • Molecular mechanisms of anchorage-independent growth exhibited by cancer cells
  • Development of Wilm’s tumor
Labo's Website

Selected publications:

  1. Watanabe, H., Ishibashi, K., Mano, H., Kitamoto, Sho., Sato, N., Hoshiba, K., Kato, Mugihiko., Matsuzawa, F., Takeuchi, Y., Shirai, T., Ishikawa, S., Morioka, Y., Imagawa, T., Sakaguchi, K., Yonezawa, S., Kon, S♯. and Fujita, Y♯. Mutant p53-expressing cells undergo necroptosis via cell competition with the neighboring normal epithelial cells.Cell Reports, 2018, 23, 3721-2729　♯equal contribution
  2. Ishibashi, K., Egami, R., Nakai, K. and Kon, S. An anti-tumorigenic role of the Warbrug effect at emergence of transformed cells. Cell Structure and Function, 2018, 43, 171-176
  3. Kon, S. Physiological and pathological relevance of cell competition in fly to mammals. Development Growth and Differentiation, 2018, 60, 14-20
  4. Kon, S＊., Ishibashi, K＊., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J., Duchen, M, R., Nam, J, M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. and Fujita, Y. Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nature Cell Biology, 2017, 19, 530-541 ＊equal contribution
  5. Kobayashi, N＊., Kon, S＊., Henmi, Y., Funaki, T., Satake, M. and Tanabe, K. The Arf GTPase-activating protein SMAP1 promotes transferrin receptor endocytosis and interacts with SMAP2. Biochemical and Biophysical Research Communications, 2014, 453, 473-479 ＊equal contribution
  6. Kon, S., Kobayashi, N. and Satake, M. Altered trafficking of mutated growth factor receptors and their associated molecules: implication for human cancers. Cellular Logistics, 2014, 4, e28461
  7. Funaki, T＊., Kon, S＊., Tanabe, K., Natsume, W., Sato, S., Shimizu, T., Yoshida, N., Wong, W, F., Ogura, A., Ogawa, T., Inoue, K., Ogonuki, N., Miki, H., Mochida, K., Endoh, K., Yomogida, K., Fukumoto, M., Horai, R., Iwakura, Y., Ito, C., Toshimori, K., Watanabe, T. and Satake, M. An Arf GAP-encoding SMAP2 is necessary for the organized vesicles budding from the Trans-Golgi-network and subsequent acrosome formation in spermiogenesis. Molecular Biology of the Cell, 2013, 24, 2633-2644 ＊equal contribution
  8. Kon, S., Minegishi, N., Tanabe, K., Watanabe, T., Funaki, T., Wong, W, F., Sakamoto, D., Higuchi, Y., Kiyonari, H., Asano, K., Iwakura, Y., Fukumoto, M., Osato, M., Sanada, S., Ogawa, S., Nakamura, T. and Satake, M. SMAP1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. Journal of Clinical Investigation, 2013, 123, 1123-1137
  9. Kon, S., Funaki, T. and Satake, M. Putative terminator and/or effector functions of Arf GAPs in the trafficking of clathrin-coated vesicles. Cellular Logistics, 2011, 1, 86-89
  10. Kon, S., Tanabe, K., Watanabe, T., Sabe, H. and Satake, M. Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1. Experimental Cell Research, 2008, 314, 1415-1428
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