Associate Professor
Shunsuke Kon
Devision of Cancer Cell Biology
Tumor biology
Tumor biology
Research theme
- Cell competition between normal epithelial cells and transformed cells
- Interaction between cancer cells and normal stromal cells
- Tumor-induced lymphangiogenesis
- Molecular mechanisms of anchorage-independent growth exhibited by cancer cells
- Development of Wilm’s tumor
Selected publications:
- Watanabe, H., Ishibashi, K., Mano, H., Kitamoto, Sho., Sato, N., Hoshiba, K., Kato, Mugihiko., Matsuzawa, F., Takeuchi, Y., Shirai, T., Ishikawa, S., Morioka, Y., Imagawa, T., Sakaguchi, K., Yonezawa, S., Kon, S♯. and Fujita, Y♯. Mutant p53-expressing cells undergo necroptosis via cell competition with the neighboring normal epithelial cells.Cell Reports, 2018, 23, 3721-2729 ♯equal contribution
- Ishibashi, K., Egami, R., Nakai, K. and Kon, S. An anti-tumorigenic role of the Warbrug effect at emergence of transformed cells. Cell Structure and Function, 2018, 43, 171-176
- Kon, S. Physiological and pathological relevance of cell competition in fly to mammals. Development Growth and Differentiation, 2018, 60, 14-20
- Kon, S*., Ishibashi, K*., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J., Duchen, M, R., Nam, J, M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. and Fujita, Y. Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nature Cell Biology, 2017, 19, 530-541 *equal contribution
- Kobayashi, N*., Kon, S*., Henmi, Y., Funaki, T., Satake, M. and Tanabe, K. The Arf GTPase-activating protein SMAP1 promotes transferrin receptor endocytosis and interacts with SMAP2. Biochemical and Biophysical Research Communications, 2014, 453, 473-479 *equal contribution
- Kon, S., Kobayashi, N. and Satake, M. Altered trafficking of mutated growth factor receptors and their associated molecules: implication for human cancers. Cellular Logistics, 2014, 4, e28461
- Funaki, T*., Kon, S*., Tanabe, K., Natsume, W., Sato, S., Shimizu, T., Yoshida, N., Wong, W, F., Ogura, A., Ogawa, T., Inoue, K., Ogonuki, N., Miki, H., Mochida, K., Endoh, K., Yomogida, K., Fukumoto, M., Horai, R., Iwakura, Y., Ito, C., Toshimori, K., Watanabe, T. and Satake, M. An Arf GAP-encoding SMAP2 is necessary for the organized vesicles budding from the Trans-Golgi-network and subsequent acrosome formation in spermiogenesis. Molecular Biology of the Cell, 2013, 24, 2633-2644 *equal contribution
- Kon, S., Minegishi, N., Tanabe, K., Watanabe, T., Funaki, T., Wong, W, F., Sakamoto, D., Higuchi, Y., Kiyonari, H., Asano, K., Iwakura, Y., Fukumoto, M., Osato, M., Sanada, S., Ogawa, S., Nakamura, T. and Satake, M. SMAP1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. Journal of Clinical Investigation, 2013, 123, 1123-1137
- Kon, S., Funaki, T. and Satake, M. Putative terminator and/or effector functions of Arf GAPs in the trafficking of clathrin-coated vesicles. Cellular Logistics, 2011, 1, 86-89
- Kon, S., Tanabe, K., Watanabe, T., Sabe, H. and Satake, M. Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1. Experimental Cell Research, 2008, 314, 1415-1428