Associate Professor

Haruo Kozono

Division of Biosignaling
Biophysics and Molecular Biology

Research theme

  • Structural fluctuation of proteins detected by X-ray single molecule analysis.
  • Brownian motions of peptide/MHC complexes that define the activation of T cells.
  • DM effects on the peptide exchange reaction.
  • Dynamic properties of diabetogenic MHC I-Ag7.

Selected publications:

  • Kozono, H., Ogawa, N., Okimoto, N., Matsushita, Y., Kozono, Y., Ohta, N., Sekiguchi, H., Kanagawa, O., and Sasaki, Y.C. Peptide dynamics in MHC class II generate flexibility for ligand recognition. Submitted.
  • Ohnuki, K., Watanabe, Y., Takahashi, Y., Kobayashi, S., Watanabe, S., Ogawa, S., Kotani, M., Kozono, H., Tanabe, K., and Abe, R. (2009). Antigen-specific CD4+ effector T cells: analysis of factors regulating clonal expansion and cytokine production: clonal expansion and cytokine production by CD4+ effector T cells. Biochem. Biophys. Res. Commun. 380:742-747.
  • Hashiguchi M., Kobori H., Ritprajak P., Kamimura Y., Kozono H., and Azuma M. (2008). Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. Proc. Natl. Acad. Sci. USA. 105:10495-10500.
  • Suzuki, H., Sekine, S., Kataoka, K., Pascual, D., Maddaloni, M., Kobayashi, R., Fujihashi, K., Kozono, H., and McGhee, J. (2008). Ovalbumin-protein sigma 1 M-cell targeting facilitates oral tolerance with reduction of antigen-specific CD4+ T cells. Gastroenterology 135:917-925.
  • Saito, K., Oda, M., Sarai, A., Azuma, T., and Kozono, H. (2004). Bound peptide-dependent thermal stability of major histocompatibility complex class II molecule I-Ek. Biochemistry 43:10186-10191.
  • Saito, K., Sarai, A., Oda, M., Azuma, T., and Kozono, H. (2003). Thermodynamic analysis of the increased stability of major histocompatibility complex class II molecule I-Ek complexed with an antigenic peptide at an acidic pH. J. Biol. Chem. 278:14732-14738.