Masato Kubo

Division of Molecular Pathology
Immunology, Allergolgy

Research theme

  • Identification of TFH cells in antibody responses to influenza virus vaccination.
  • The role of TFH cells in IgE responses during allergy.
  • The role of TH2 cells in allergic inflammatory responses.
  • The mechanisms by which immunological memory is established.
  • Identification of the epigenetic landscape in cytokine gene expression.
  • The role of innate immune cells (e.g., mast cells, basophils, innate lymphoid cells) in inflammatory responses.
  • In vivo imaging of the cytokine network in immune responses.

Publications in 2012

  • Motomura, Y., Morita, H., Moro, K., Nakae, S., Artis, D., Koyasu,S., Kubo, M. Basophil-derived IL-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. Immunity 40, Issue 5, p758–71, May 2014.
  • Kubo, M. TCF-1 and LEF-1 help launch the TFH program, Nature Immunology, 16(9):900-1, Sep 2015.
  • Miyauchi, K., Sugimoto-Ishige, A., Harada, Y., Adachi, Y., Usami, Y., Kaji, T., Hasegawa, H., Watanabe, T., Hijikata, A., Fukuyama, S., Maemura, T., Ohara, O., Kawaoka, Y., Takahashi, Y., Takemori, T., and Kubo, M. Protective neutralizing influenza antibody response in the absence of T follicular helper cells. Nature Immunology 17(12):1447-1458, Dec 2016.
  • Dominguez-Huttinger, E. E., Christodoulides, P., Miyauchi, K., Irvine, AD., Okada-Hatakeyama, M., Kubo, M. and Reiko J Tanaka, RJ., Mathematical modeling of atopic dermatitis reveals “double-switch” mechanisms underlying 4 common disease phenotypes. J. Allergy Clin Immunol.139(6):1861-1872 e7, Jun 2017.
  • Wang,Y., Zheng Kuang, Xiaofei Yu, Kelly A. Ruhn, Kubo, M., and Lora V. Hooper, The intestinal microbiota regulates body composition through NFIL3 and the circadian clock. Science 357(6354):912-916,Sep 2017.
  • Kubo, M., Mast cells and basophils in allergic inflammation, Current Opinion in Immunology Current Opinion in Immunology, 54, 74-79, October 2018.
  • Takamura, S., Kato, S., Motozono, C., Shimaoka, T., Ueha, S., Matsuo, K., Miyauchi, K., Masumoto, T., Katushima, A., Nakayama, T., Tomura, M., Matsushima, K., Kubo, M. and Miyazawa, M. Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung, J. Exp. Med. 216(12):2736-2747 Dec 2019.
  • Sasaki, T., Yajima, T., Shimaoka, T., Ogawa, S., Saito, T., Yamaoka, K., Takeuchi, T., Kubo, M. Synergistic effect of IgG4 antibody and CTLs causes tissue inflammation in IgG4-related disease. Int. Immunol. 32(3), 163-174, Mar 2020.
  • Kubo, M. Miyauchi, K. Breadth of Antibody Responses during Influenza Virus Infection and Vaccination, Trends in Immunology. 2020 Apr 4. doi: 10.1016/