Scientists

Professor

Ryo Goitsuka

Division of Cell Fate Regulations
Developmental Immunology, Regenerative Biology

Research theme

  • Identification of mesenchymal stem cells that generate hematopoiesis- and immune response-supportive microenvironments in the spleen.
  • Investigation of the role of postnatal epithelial progenitor cells in the maintenance of the thymic microenvironment necessary for T cell generation and selection.
  • Investigation of Hippo pathway-mediated regulation of the size and function of lymphoid organs.
  • Generation of artificial lymphoid/hematopoietic tissues from niche stem cells for application in regenerative medicine.
Labo's Website

Selected publications:

  1. Ueno, Y., Fujisaki, K., Hosoda, S., Amemiya, Y., Okazaki, S., Notsu, C., Nishiyama, C. Mabuchi, Y., Matsuzaki, Y., Oda, A, and Goitsuka, R.: Transcription factor Tlx1 marks a subset of lymphoid tissue organizer-like mesenchymal progenitor cells in the neonatal spleen. Scientific Reports, 9 (1): 20418. (2019)
  2. Namekata, M, Yamamoto, M. and Goitsuka, R.: Nuclear localization of Meis1 in dermal papilla promotes hair matrix proliferation in the anagen phase of hair cycle. Biochem. Biophys. Res. Commun. 519(4):727-733.(2019)
  3. Oda, A, Ueno, Y.,Hosoda, S., Amemiya, Y., Notsu,C., Tezuka, T., Kasahara, T., Nishiyama, N. and Goitsuka, R.: Niche-induced extramedullary hematopoiesis in the spleen is regulated by the transcription factor Tlx1. Scientific Reports, 8:8308, (2018)
  4. Tashiro, Y., Murakami, A., Hara, Y., Shimizu, T., Kubo, M., Goitsuka, R., Kishimoto, K. and Azuma, T.:High-affinity IgM+ memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen. Scientific Reports, 8:14559 (2018)
  5. Kawai, Y., Oda, A., Kanai, Y., and Goitsuka, R.: Germ cell-intrinsic requirement for the homeodomain transcription factor PKnox1/Prep1 in adult spermatogenesis. PLosOne, 2018, 13(1): e0190702.
  6. Owa, T, Taya S, Miyashita, S, Yamashita, M, Adachi, T, Yamada, K, Yokoyama, M, Aida, S, Nishioka, T, Inoue, YU, Goitsuka, R, Nakamura, T, Inoue, T, Kaibuchi, K and Hoshino, M.: Meis1 coordinates cerebellar granule cell development by regulating Pax6 transcription, BMP signaling and Atoh1 degradation. J Neurosci., 2018, 38(5):1277-1294.
  7. 7Yokoyama, T., Nakatake, M., Kuwata, T., Goitsuka, R., Tsutsumi, S., Aburatani, H., Valk, P. J. M., Delwel, R. and Nakamura, T.: Tranactivation of Styl1/Slp1 by Meis1 promotes CXCL12/CXCR4 signaling and myeloid leukemogenesis in vivo. J. Clin. Invest., 2016, 126:1664-1678
  8. Yoshioka, K., Kawai, Y., Oda, A., Notsu, C. Mabuchi, Y., Suzuki, S., Matsuzaki, Y., and Goitsuka, R.: Loss of Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in The Bone Marrow. Plos One, 2015, 10, e0136107.
  9. Tashiro, Y., Murakami, A., Goitsuka, R., Shimizu, T., Kishimoto, H., and Azuma, T.: An asymmetric antibody repertoire is shaped between plasmablasts and plasma cells after secodary immunization with (4-hydroxy-3-nitrophenyl)acetyl chicken gamma-globulin. Int. Immunol., 2015, 27 (12):609-620.
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