Scientists

Junior Associate Professor

Shuhei Ogawa

Divison of Integrated Research
Immunobiology, Developmental Engineering

Research theme

  • Analysis of costimulatory signaling in activation and differentiation of T cells
  • The role of SCFA (short-chain fatty acid) and its receptor on T cell function
  • Generation of gene-modified mice

Selected publications:

  1. Ogawa S, Abe R. Signal Transduction Via Co-stimulatory and Co-inhibitory Receptors. Adv Exp Med Biol. 2019;1189:85-133.
  2. Wakamatsu E, Omori H, Tabata Y, Akieda Y, Watanabe S, Ogawa S, Abe R. CD28 co-stimulation is dispensable for the steady state homeostasis of intestinal regulatory T cells. Int. Immunol. 30(4): 171-180, 2018
  3. Inaba S, Numoto N, Ogawa S, Morii H, Ikura T, Abe R, Ito N, Oda M. Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins. J Biol Chem. 292(3): 1052-1060, 2017
  4. Ohtsuka S, Ogawa S, Wakamatsu E, Abe R. Cell cycle arrest caused by MEK/ERK signaling is a mechanism for suppressing growth of antigen-hyperstimulated effector T cells. Int Immunol. 28(11): 547-557, 2016
  5. Akieda Y, Wakamatsu E, Nakamura T, Ishida Y, Ogawa S, Abe R. Defects in regulatory T cells due to CD28 deficiency induce a qualitative change of allogeneic immune response in chronic graft-versus-host disease. J Immunol. 194(9): 4162-74, 2015
  6. Obata Y, Toyoshima S, Wakamatsu E, Suzuki S, Ogawa S, Esumi H, Abe R. Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation. Nat Commun. 5:5715, 2014
  7. Higo K, Oda M, Morii H, Takahashi J, Harada Y, Ogawa S, Abe R. Quantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K. Immunol Invest. 43(3): 278-91, 2014
  8. Ogawa S, Watanabe M, Sakurai Y, Inutake Y, Watanabe S, Tai X, Abe R. CD28 signaling in primary CD4(+) T cells: identification of both tyrosine phosphorylation-dependent and phosphorylation-independent pathways. Int Immunol. 25(12): 671-81, 2013
  9. Watanabe M, Nakajima S, Ohnuki K, Ogawa S, Yamashita M, Nakayama T, Murakami Y, Tanabe K, Abe R. AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling. Eur J Immunol. 42(7): 1850-62, 2012
  10. Watanabe S, Ohnuki K, Hara Y, Ishida Y, Ikarashi Y, Ogawa S, Kishimoto H, Tanabe K, Abe R. Suppression of Con A-induced hepatitis induction in ICOS-deficient mice. Immunol Lett. 128(1): 51-8, 2010
  11. Takeda K, Harada Y, Watanabe R, Inutake Y, Ogawa S, Onuki K, Kagaya S, Tanabe K, Kishimoto H, Abe R. CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis. Int Immunol. 20(12):1507-15, 2008
  12. Watanabe M, Takagi Y, Kotani M, Hara Y, Inamine A, Hayashi K, Ogawa S, Takeda K, Tanabe K, Abe R. Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J Immunol. 180(8):5222-34, 2008
  13. Suzuki T, Ogawa S, Tanabe K, Tahara H, Abe R, Kishimoto H. Induction of antitumor immune response by homeostatic proliferation and CD28 signaling. J Immunol. 180(7):4596-605, 2008
  14. Watanabe R, Harada Y, Takeda K, Takahashi J, Ohnuki K, Ogawa S, Ohgai D, Kaibara N, Koiwai O, Tanabe K, Toma H, Sugamura K, Abe R. Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation. J Immunol. 177(2):1085-91, 2006
  15. Watanabe S, Ogawa S, Hara Y, Tanabe K, Toma H, Abe R. Expression level of costimulatory receptor ICOS is critical for determining the polarization of helper T cell function. Transpl Immunol. 15(4):255-63, 2006
  16. Kotani M, Hirata K, Ogawa S, Habiro K, Ishida Y, Tanuma S, Horai R, Iwakura Y, Kishimoto H, Abe R. CD28-dependent differentiation into the effector/memory phenotype is essential for induction of arthritis in interleukin-1 receptor antagonist-deficient mice. Arthritis Rheum. 54(2):473-81, 2006
  17. Okano K, Nitta K, Ogawa S, Horita S, Habiro K, Nihei H, Abe R. Effects of double blockade of CD28 and inducible-costimulator signaling on anti-glomerular basement membrane glomerulonephritis. J Lab Clin Med. 144(4):183-92, 2004
  18. Nitta K, Horita S, Ogawa S, Matsumoto M, Hara Y, Okano K, Hayashi T, Abe R, Nihei H. Resistance of CD28-deficient mice to autologous phase of anti-glomerular basement membrane glomerulonephritis. Clin Exp Nephrol. 2003 Jun;7(2):104-12.
  19. Ogawa S, Nagamatsu G, Watanabe M, Watanabe S, Hayashi T, Horita S, Nitta K, Nihei H, Tezuka K, Abe R. Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host disease. J Immunol. 167(10):5741-8, 2001
  20. Harada Y, Tokushima M, Matsumoto Y, Ogawa S, Otsuka M, Hayashi K, Weiss BD, June CH, Abe R. Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo. J Immunol. 166(6):3797-803, 2001
  21. Ogawa S, Nitta K, Hara Y, Horita S, Nihei H, Abe R. CD28 knockout mice as a useful clue to examine the pathogenesis of chronic graft-versus-host reaction. Kidney Int. 58(5):2215-20, 2000
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