Scientists

Professor

Takeshi Nitta

Division of Molecular Pathology
Immunology and Molecular Biology

Research theme

  • Mechanisms of thymic microenvironment formation
  • Positive and negative selections of T cells in the thymus
  • Involution and regeneration of the thymus
  • Mechanisms of gamma/delta T cell development
  • Evolutionary origin of the immune system
Labo's Website

Selected publications:

  1. Muro R, Nitta T, Nitta S, Tsukasaki M, Asano T, Nakano K, Okamura T, Nakashima T, Okamoto K, Takayanagi H. Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity. J Clin Invest, in press.
  2. Ota A, Iguchi T, Nitta S, Muro R, Mino N, Tsukasaki M, Penninger JM, #Nitta T, Takayanagi H. Synchronized development of thymic eosinophils and thymocytes. Int Immunol, dxae037, 2024. doi: 10.1093/intimm/dxae037. (#, corresponding author)
  3. Muro R, Narita T, #Nitta T, Takayanagi H. Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation. Front Immunol 13, 1045881, 2023. doi: 10.3389/fimmu.2022.1045881. (#, corresponding author)
  4. #Nitta T. Mesenchymal stromal cells in the thymus. Inflamm Regen, 42, 33, 2022. doi: 10.1186/s41232-022-00219-5. (#, corresponding author)
  5. Mino N, Muro R, Ota A, Nitta S, Lefebvre V, #Nitta T, Fujio K, Takayanagi H. The transcription factor Sox4 is required for thymic tuft cell development. Int Immunol, 34, 45-52, 2022. doi: 10.1093/intimm/dxab098. (#, corresponding author)
  6. #Nitta T, Ota A, Iguchi T, Muro R, Takayanagi H. The fibroblast: an emerging key player in thymic T cell selection. Immunol Rev, 302, 68-85, 2021. doi:10.1111/imr.12985 (#, corresponding author)
  7. #Nitta T, Takayanagi H. Non-epithelial thymic stromal cells: Unsung heroes in thymus organogenesis and T cell development. Front Immunol, 11, 620894, 2021. doi: 10.3389/fimmu.2020.620894 (#, corresponding author)
  8. #Nitta T, Tsutsumi M, Nitta S, Muro R, Suzuki EC, Nakano K, Tomofuji Y, Sawa S, Okamura T, Penninger JM, Takayanagi H. Fibroblasts as a source of self-antigens for central immune tolerance. Nat Immunol, 21, 1172-1180, 2020. doi: 10.1038/s41590-020-0756-8 (#, corresponding author)
  9. Muro R, Takayanagi H, #Nitta T. Retroviral gene transduction into T-cell progenitors for analysis of T cell development in the thymus. Methods Mol Biol, 2111, 193-203, 2020. doi: 10.1007/978-1-0716-0266-9_16. (#, corresponding author)
  10. Muro R, Takayanagi H, #Nitta T. T cell receptor signaling for γδT cell development. Inflamm Regen, 39,6, 2019. doi.org/10.1186/s41232-019-0095-z. (#, corresponding author)
  11. *Narita T, *Nitta T, Nitta S, Okamura T, Takayanagi H. Mice lacking all of the Skint family genes. Int Immunol, 30, 301-309, 2018. doi:10.1093/intimm/dxy030 (*, co-first author)
  12. *Muro R, *#Nitta T, Nakano K, Okamura T, #Takayanagi H, #Suzuki H. gdTCR recruits the Syk/PI3K axis to drive proinflammatory differentiation program. J Clin Invest, 128, 415-426, 2018. doi: 10.1172/JCI95837. (*, co-first author; #, corresponding author)
  13. Nitta T, Kochi Y, Muro R, Tomofuji, Y, Okamura T, Murata S, Suzuki H, Sumida T, Yamamoto K, Takayanagi H. Human thymoproteasome variations influence CD8 T cell selection. Sci Immunol, 2, eaan5165, 2017. Doi: 1126/sciimmunol.aan5165.
  14. *Nitta T, *Suzuki H. Thymic stromal cell subsets for T cell development. Cell Mol Life Sci, 73, 1021-1037, 2016. DOI 10.1007/s00018-015-2107-8 (*, corresponding author)
  15. Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata S, Suzuki H. The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gdT cells. EMBO Rep, 16, 638-653, 2015.
  16. *Nakagawa Y, *Ohigashi I, *Nitta T, *Sakata M, Tanaka K, Murata S, Kanagawa O, Takahama Y. Thymic nurse cells provide microenvironment for secondary TCRa rearrangement in cortical thymocytes. Proc Natl Acad Sci USA, 109, 20572-20577, 2012. (*, equal contribution)
  17. Nitta T, Murata S, Sasaki K, Fujii H, Mat Ripen A, Ishimaru N, Koyasu S, Tanaka K, Takahama Y. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity 32, 29-40, 2010.
  18. Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y. CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens. Proc Natl Acad Sci USA 106, 17129-17133, 2009.
  19. *Hikosaka Y, *Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29, 438-450, 2008. (*, equal contribution)
  20. Nitta T, Nasreen M, Seike T, Goji A, Ohigashi I, Miyazaki T, Ohta T, Kanno M, Takahama Y. IAN family critically regulates survival and development of T lymphocytes. PLoS Biology 4(4):e103, 2006.
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