Metabolic reprogramming induces germinal center B cell differentiation
through Bcl6 locus remodeling
Kei Haniuda, Saori Fukao, Daisuke Kitamura
Cell Reports. 2020 Nov 3;33(5):108333.
DOI: 10.1016/j.celrep.2020.108333

https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31322-X

Highlights
●IL-4-signaling induces Bcl6 expression and GC B cell differentiation
●IL-4 alters TCA cycle to accumulate αKG, a cofactor for H3K27-demethylase
●STAT6 recruits H3K27-demethylase UTX, leading to activation of the Bcl6 locus
●GC B cell development requires αKG and enzymes regulating αKG level