生命研セミナー 慶應義塾大学医学部 吉村昭彦 博士RIBS SEMINAR Dr. Akihiko Yoshimura Keio University School of Medicine

日時 2022年10月19日(水)16:30-18:00
場所 生命医科学研究所2階大講義室

演者 吉村昭彦 博士

演題 免疫寛容の分子機構と制御性T細胞



Date: Oct. 19 (Wed)
Time: 16:30-18:00
Place: Research Institute for Biomedical Science,
Tokyo University of Science, Conference Room, 2F.
Application form for Zoom (until 12:00 on Oct. 19)

Speaker: Dr. Akihiko Yoshimura
Professor, Department of Microbiology and Immunology,
Keio University School of Medicine

Title: Molecular mechanism of immune tolerance and regulatory T cells

Immune tolerance is the absence or suppressive state of specific immune responses to self or harmless substances such as pollen. When immune tolerance breaks down, autoimmune and allergic diseases will occur. T cells play central in immune tolerance. In addition to inhibitory receptors that suppress antigen receptor (TCR) signaling, SOCS, a molecule that suppresses cytokine signaling, is involved in immune tolerance. Regulatory T cells (Tregs) are also important cells involved in immune tolerance. We have discovered a transcription factor NR4a, which is essential for inducing Tregs. NR4a has been shown to induce suppressive state (exhaustion or anergy) of not only Tregs but also T cells in general. In this seminar, I will discuss these molecular mechanisms of immune tolerance and the recent discovery of Tregs in the brain.

Prof. Yoichiro Iwakura