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疾患モデルマウスリストMouse list for Animal Disease Models

Disease models and research tools

  • A: available
  • B: may be delayed
  • C: only frozen embryos are available

Iwakura Lab PI: Dr. Yoichiro Iwakura (iwakura[at]rs.tus.ac.jp)

Knockout mouse Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
DCIR (dendritic cell immunoreceptor):Clec4a2 C A A - - Nat Med 14:176-80(2008)
Dectin-2:Clec4n C C B - - Immunity 32: 681-691 (2010)
Dectin-1:Clec7a C A A - - Nat Immunol 8:39-49(2007)
IFNγ:Ifng - B C C - J Immunol 159:1418-28(1997)
IL-1α:Il1a - B A - - J Exp Med 187:1463-75 (1998)
IL-1β:Il1b - B A - - J Exp Med 187:1463-75 (1998)
IL-1α/β:Il1a/Il1b - B A - C J Exp Med 187:1463-75 (1998)
IL-1 Receptor antagonist:Il1rn - C B - C J Exp Med 187:1463-75 (1998)
IL-1 Receptor type2:Il1r2 - C C - - J Immunol 194:3156-3168 (2015)
IL-1F6:Il1f6 - C C - - J Immunol 201:167-182 (2018)
IL-17A:Il17a C A A - C Immunity 17: 375-87 (2002)
IL-17F:Il17f C C A - - Immunity 30: 108-19 (2009)
IL-17A/F:Il17a/Il17f C A A - - Immunity 30: 108-19 (2009)
TNFα:Tnfa - C C - - Lab Invest 77: 647-58 (1997) 3
CC chemokine receptor 8:Ccr8 - C C - - Int Immunol 27:169-81 (2015)
CXC chemokine receptor 4:Cxcr4 - C C - - Arthritis Res Ther 12: R188 (2010)
polymeric immunoglobulin receptor:Pigr - - - - - J Immunol 163: 5367-73 (1999) 5
Melanocortin 2 receptor:Mc2r - C - - - Proc Natl Acad Sci USA 103: 18205-10 (2007)
βGlcNAcβ1,4-galactosyltransferase1:B4galt1 C - - - - EMBO J 16: 1850-7 (1997)
Protein tyrosine phospatase recepter typeδ:Ptprd - - - - - EMBO J 19: 2775-85 (2000) 7
docking protein 7: Dok7 C - - - - Science 312:1802-5 (2006) 6
Eph receptor A2:Epha2 C - - - - Mech Div 102: 95-102 (2001)
guanine nucleotide binding protein (G protein), β1:Gnb1 C C - - - Dev Dyn 239:1089-101 (2010)
EST gene 4933427D06Rik:4933427D06Rik C C - - - -
transgenic mouse Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
Human T-cell Leukemia Virus type 1(pX) gene - C - C - Science 253: 1026-8 (1991) 7
c-fms promoter/tax gene - - - C - J Immunol 162: 2956-63 (1999)
Human Immunodeficiency Virus (RT-) gene - C - C - AIDS 6: 1069-75 (1992)
CD4 promoter/vpr gene - - - C - Virology 285: 181-92 (2001)
CD4 promoter/human CD4 gene - - - C - J Virol 81:677-88 (2007)
metallothioneine promoter/Ifnb gene - - - C - EMBO J 7: 3757-62 (1988)
SAP promoter/RANKL - C - - - J Bone Miner Metab 20: 337-44 (2002) 4
PGK promoter/neomycin phosphotransferase gene - - - C - -
CD34 promoter/Cre recombinase gene C - - - - - 7

** mice were backcrossed more than 8 generations except for 129*B6 intercrossed mice

Additional permission from the following developers is required.
  • 1: Dr. M Aguet
  • 2: Dr. M Kopf
  • 3: Dr. K Sekikawa
  • 4: Snow Brand Milk Products Co. Ltd.
  • 5: You can obtain from Yakult Central Institute for Microbiological Research
  • 6: Dr. Y Yamanashi
  • 7: You can obtain from RIKEN BRC

Kubo Lab PI: Dr. Masato Kubo (raysolfc[at]rcai.riken.jp)

enhancer/promoter KO Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
pIl13 KO
Il4 HS2 KO
Il4 3’UTR KO
Il4 HS4 KO
Il4 CNS2 KO
Il4 KO
Il4r KO
Ifng KO
Il6 KO
Il10 KO
Il17a KO
Il21 f/f
Stat6 KO
Stat3 f/f
E4bp4 KO
E4bp4 f/f
Rbpj f/f
Gata3 f/f
Bcl6 f/f
Rag1 KO
Cd3 KO
SOCS1 f/f
SOCS3 f/f
CIS1 Tg
SOCS1 Tg
SOCS3 Tg
SOCS5 Tg
OTII Tg
cytokine reporter mice Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
IL-4GFP knock-in
IL-4 hCD2 bac Tg
IL-4 CNS2-GFP Tg
IL-10 venus knock-in
IL-13 tomato knock-in
IL-21 hCD2 bac Tg
IL-17GFP knock-in
IFNγ venus bac Tg
IFNβ Cherry bac Tg
Mas-TRCK
Bas-TRECK

Kitamura Lab PI: Dr. Daisuke Kitamura (kitamura[at]rs.noda.tus.ac.jp)

Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
muMT KO, IgH Cmu, neo. B Nature 350:423-6 (1991)
HS1 KO, neo, LacZ C EMBOJ 14:3664-78 (1995)
DNase g MT, KO, DNase g , neo B unpublished
BASH KO, KO BASH (BLNK/SLP-65), neo B Immunity 18:825-36 (2003)
RAG2 KO, KO, RAG2, neo B Cell 68:855-67 (1992)
PKCd KO, KO, PKCd (delta), neo B Nature 416:865-9 (2002)
Hy10, KO(KI)/Tg, IgH/kappa-Tg, VDJ9, kappa5 B Science 315:528-31 (2007)
VH B1-8Hi, KO (KI), IgH, VH B1-8, lox-P B Cell 90:1073-83 (1997)
CD19-Cre, KO (KI), CD19, neo, Cre, C57BL/6 B Nature 376:352-5 (1995)
IgG1-Cre, KO (KI), IgH Cgamma, Cre gene, lox-P B PNAS 103:7396-401 (2006)

Goiizuka Lab PI : Dr. Ryo Goitsuka (ryogoi[at]rs.noda.tus.ac.jp)

Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
Clnk KO (C57BL/6J)：signal transduction
Gpr141 KO (B6/129)：GPCR
Conditional knockout（floxed）
Meis1(C57BL/6J)：transcription factor
pKnox1 (Prep1, Meis4)(C57BL/6J)：transcription factor
Cre driver, reporter（knockin）
Tlx1-CreER-ires2-Venus (C57BL/6J)：transcription factor

Furuichi Lab PI: Dr. Teiichi Furuichi (tfuruichi[at]rs.tus.ac.jp)

Genetic background**
Original mouse lines 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
1NM13 Tg: IP3R1 promoter (1kb)-nls-lacZ
4NM1Tg: IP3R1 promoter (4kb)-nls-lacZ
CAPS2 KO: Dense-core vesicle secretion-related protein
CAPS2 dex3 KI: CAPS2 deletion of exon3
CAPS1 cKO: Dense-core vesicle secretion-related protein CAPS1 gene floxed mouse
Mouse lines obtained from the public resources or collaborators 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
reeler: Spontaneous mutant mouse (loss of reelin) provided provided by RIKEN ( M. Ogawa)
Cdf：Spontaneous mutant mouse (loss of Catna2) provided by JAX
KIAA1768 KO: RasGEF very-KIND gene provided by RIKEN BRC (M. Nakayama, KAZUSA)
p130Cas cKO: p130Cas floxed mouse provided by RIKEN BRC (Dr. H. Honda, Hiroshima Univ)
GAD67-GFP KI provided by RIKEN BRC (Y. Yanagisawa, Gunma Univ)
TH-GFP Tg: Tyrosine hydroxylase-GFP provided by RIKEN BRC (K. Kobayashi, Fukushima Med Univ)
YFP-H: YFP transgenic mouse H line
CAG-Cre Tg: CAG promoter-Cre
Emx1-Cre: Transcription factor Emx1-Cre KI provided by RIKEN BRC (S. Itohara, RIKEN)
Ptf1a-Cre: Transcription factor Ptf1a-Cre KI provided by RIKEN BRC (M. Hoshino)
CaMKII-Cre Tg: Protein kinase CaMKII-Cre provided by RIKEN BRC (K. Mikoshiba, RIKEN)
DBH-Cre: dopamine-beta-hydroxylase-Cre KI provided by RIKEN BRC (K. Kobayashi, Fukushima Med Univ)
Wnt1-Cre Tg provided by JAX
ROSA26-CreER Tg provided by RIKEN BRC (M. Okabe, Osaka Univ)

Higami LabPI: Dr. Yoshikazu Higami　(higami[at]rs.tus.ac.jp)

Knockout Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
Srebp1c KO：transcription factor B
Please contact the principle investigators (PI) to obtain the mice listed above.

Disease models and research tools

  • A: available
  • B: may be delayed
  • C: only frozen embryos are available

Iwakura Lab PI: Dr. Yoichiro Iwakura (iwakura[at]rs.tus.ac.jp)

Knockout mouse Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
DCIR (dendritic cell immunoreceptor):Clec4a2 C A A – – Nat Med 14:176-80(2008)
Dectin-2:Clec4n C A A – – Immunity 32: 681-691 (2010)
Dectin-1:Clec7a C A A – – Nat Immunol 8:39-49(2007)
IFNγ:Ifng – A A C – J Immunol 159:1418-28(1997)
IFNγ Receptor:Ifngr1 – C – – – Science 259:1742-5(1993) 1
IL-1α:Il1a – A A – – J Exp Med 187:1463-75 (1998)
IL-1β:Il1b – A A – – J Exp Med 187:1463-75 (1998)
IL-1α/β:Il1a/Il1b – A A – C J Exp Med 187:1463-75 (1998)
IL-1 Receptor antagonist:Il1rn – A A – C J Exp Med 187:1463-75 (1998)
IL-1F6:Il1f6 – C C – – –
IL-4:Il4 – C C – – Nature 362: 245-8 (1993) 2
IL-6:Il6 – B B – – Nature 368: 339-42 (1994) 2
IL-17:Il17a C A A – C Immunity 17: 375-87 (2002)
IL-17F:Il17f C A A – – Immunity 30: 108-19 (2009)
IL-17A/F:
Il17a/Il17f C A A – – Immunity 30: 108-19 (2009)
TNFα:
Tnfa – A A – – Lab Invest 77: 647-58 (1997) 3
CC chemokine receptor 8:Ccr8 – C A – – –
CXC chemokine receptor 4:Cxcr4 – A C – – Arthritis Res Ther 12: R188 (2010)
polymeric immunoglobulin receptor:Pigr – C – – – J Immunol 163: 5367-73 (1999) 5
Melanocortin 2 receptor:Mc2r – C – – – Proc Natl Acad Sci USA 103: 18205-10 (2007)
βGlcNAcβ1,4-galactosyltransferase1:B4galt1 C – – – – EMBO J 16: 1850-7 (1997)
Protein tyrosine phospatase recepter typeδ:Ptprd C C – – – EMBO J 19: 2775-85 (2000)
docking protein 7: Dok7 C – – – – Science 312:1802-5 (2006) 6
Eph receptor A2:Epha2 C – – – – Mech Div 102: 95-102 (2001)
guanine nucleotide binding protein (G protein), β1:Gnb1 C C – – – Dev Dyn 239:1089-101 (2010)
EST gene 4933427D06Rik:4933427D06Rik C C – – – –
transgenic mouse Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
Human T-cell Leukemia Virus type 1(pX) gene – C B C – Science 253: 1026-8 (1991)
c-fms promoter/tax gene – – – C – J Immunol 162: 2956-63 (1999)
Human Immunodeficiency Virus (RT-) gene – A – C – AIDS 6: 1069-75 (1992)
CD4 promoter/vpr gene – – – C – Virology 285: 181-92 (2001)
CD4 promoter/human CD4 gene – – – C – –
metallothioneine promoter/Ifnb gene – – – C – EMBO J 7: 3757-62 (1988)
SAP promoter/RANKL – C – – – J Bone Miner Metab 20: 337-44 (2002) 4
PGK promoter/neomycin phosphotransferase gene – – – C – –
CD34 promoter/Cre recombinase gene – C – – – –
CD19 promoter/Cre recombinase gene – C – – – –

** mice were backcrossed more than 8 generations except for 129*B6 intercrossed mice

Additional permission from the following developers is required.

  • 1: Dr. M Aguet
  • 2: Dr. M Kopf
  • 3: Dr. K Sekikawa
  • 4: Snow Brand Milk Products Co. Ltd.
  • 5: Yakult Central Institute for Microbiological Research
  • 6: Dr. Y Yamanashi.

Kubo Lab PI: Dr. Masato Kubo (raysolfc[at]rcai.riken.jp)

enhancer/promoter KO Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
pIl13 KO
Il4 HS2 KO
Il4 3’UTR KO
Il4 HS4 KO
Il4 CNS2 KO
Il4 KO
Il4r KO
Ifng KO
Il6 KO
Il10 KO
Il17a KO
Il21 f/f
Stat6 KO
Stat3 f/f
E4bp4 KO
E4bp4 f/f
Rbpj f/f
Gata3 f/f
Bcl6 f/f
Rag1 KO
Cd3 KO
SOCS1 f/f
SOCS3 f/f
CIS1 Tg
SOCS1 Tg
SOCS3 Tg
SOCS5 Tg
OTII Tg
cytokine reporter mice Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
IL-4GFP knock-in
IL-4 hCD2 bac Tg
IL-4 CNS2-GFP Tg
IL-10 venus knock-in
IL-13 tomato knock-in
IL-21 hCD2 bac Tg
IL-17GFP knock-in
IFNγ venus bac Tg
IFNβ Cherry bac Tg
Mas-TRCK
Bas-TRECK

Kitamura Lab PI: Dr. Daisuke Kitamura (kitamura[at]rs.noda.tus.ac.jp)

Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
muMT KO, IgH Cmu, neo. B Nature 350:423-6 (1991)
HS1 KO, neo, LacZ C EMBOJ 14:3664-78 (1995)
DNase g MT, KO, DNase g , neo B unpublished
BASH KO, KO BASH (BLNK/SLP-65), neo B Immunity 18:825-36 (2003)
RAG2 KO, KO, RAG2, neo B Cell 68:855-67 (1992)
PKCd KO, KO, PKCd (delta), neo B Nature 416:865-9 (2002)
Hy10, KO(KI)/Tg, IgH/kappa-Tg, VDJ9, kappa5 B Science 315:528-31 (2007)
VH B1-8Hi, KO (KI), IgH, VH B1-8, lox-P B Cell 90:1073-83 (1997)
CD19-Cre, KO (KI), CD19, neo, Cre, C57BL/6 B Nature 376:352-5 (1995)
IgG1-Cre, KO (KI), IgH Cgamma, Cre gene, lox-P B PNAS 103:7396-401 (2006)

Goiizuka Lab PI : Dr. Ryo Goitsuka (ryogoi[at]rs.noda.tus.ac.jp)

Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
Clnk KO (C57BL/6J)：signal transduction
Gpr141 KO (B6/129)：GPCR
Conditional knockout（floxed）
Meis1(C57BL/6J)：transcription factor
pKnox1 (Prep1, Meis4)(C57BL/6J)：transcription factor
Cre driver, reporter（knockin）
Tlx1-CreER-ires2-Venus (C57BL/6J)：transcription factor

Furuichi Lab PI: Dr. Teiichi Furuichi (tfuruichi[at]rs.tus.ac.jp)

Genetic background**
Original mouse lines 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
1NM13 Tg: IP3R1 promoter (1kb)-nls-lacZ
4NM1Tg: IP3R1 promoter (4kb)-nls-lacZ
CAPS2 KO: Dense-core vesicle secretion-related protein
CAPS2 dex3 KI: CAPS2 deletion of exon3
CAPS1 cKO: Dense-core vesicle secretion-related protein CAPS1 gene floxed mouse
Mouse lines obtained from the public resources or collaborators 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
reeler: Spontaneous mutant mouse (loss of reelin) provided provided by RIKEN ( M. Ogawa)
Cdf：Spontaneous mutant mouse (loss of Catna2) provided by JAX
KIAA1768 KO: RasGEF very-KIND gene provided by RIKEN BRC (M. Nakayama, KAZUSA)
p130Cas cKO: p130Cas floxed mouse provided by RIKEN BRC (Dr. H. Honda, Hiroshima Univ)
GAD67-GFP KI provided by RIKEN BRC (Y. Yanagisawa, Gunma Univ)
TH-GFP Tg: Tyrosine hydroxylase-GFP provided by RIKEN BRC (K. Kobayashi, Fukushima Med Univ)
YFP-H: YFP transgenic mouse H line
CAG-Cre Tg: CAG promoter-Cre
Emx1-Cre: Transcription factor Emx1-Cre KI provided by RIKEN BRC (S. Itohara, RIKEN)
Ptf1a-Cre: Transcription factor Ptf1a-Cre KI provided by RIKEN BRC (M. Hoshino)
CaMKII-Cre Tg: Protein kinase CaMKII-Cre provided by RIKEN BRC (K. Mikoshiba, RIKEN)
DBH-Cre: dopamine-beta-hydroxylase-Cre KI provided by RIKEN BRC (K. Kobayashi, Fukushima Med Univ)
Wnt1-Cre Tg provided by JAX
ROSA26-CreER Tg provided by RIKEN BRC (M. Okabe, Osaka Univ)

Higami LabPI: Dr. Yoshikazu Higami　(higami[at]rs.tus.ac.jp)

Knockout Genetic background**
Strains 129*B6 C57BL/6J BALB/cA C3H/HeN NOD Reference note
Srebp1c KO：transcription factor B

Please contact the principle investigators (PI) to obtain the mice listed above.