Disease models and research tools
- A: available
- B: may be delayed
- C: only frozen embryos are available
Iwakura Lab PI: Dr. Yoichiro Iwakura (iwakura[at]rs.tus.ac.jp)
Knockout mouse | Genetic background** | ||||||
---|---|---|---|---|---|---|---|
Strains | 129*B6 | C57BL/6J | BALB/cA | C3H/HeN | NOD | Reference | note |
DCIR (dendritic cell immunoreceptor):Clec4a2 | C | A | A | - | - | Nat Med 14:176-80(2008) | |
Dectin-2:Clec4n | C | C | B | - | - | Immunity 32: 681-691 (2010) | |
Dectin-1:Clec7a | C | A | A | - | - | Nat Immunol 8:39-49(2007) | |
IFNγ:Ifng | - | B | C | C | - | J Immunol 159:1418-28(1997) | |
IL-1α:Il1a | - | B | A | - | - | J Exp Med 187:1463-75 (1998) | |
IL-1β:Il1b | - | B | A | - | - | J Exp Med 187:1463-75 (1998) | |
IL-1α/β:Il1a/Il1b | - | B | A | - | C | J Exp Med 187:1463-75 (1998) | |
IL-1 Receptor antagonist:Il1rn | - | C | B | - | C | J Exp Med 187:1463-75 (1998) | |
IL-1 Receptor type2:Il1r2 | - | C | C | - | - | J Immunol 194:3156-3168 (2015) | |
IL-1F6:Il1f6 | - | C | C | - | - | J Immunol 201:167-182 (2018) | |
IL-17A:Il17a | C | A | A | - | C | Immunity 17: 375-87 (2002) | |
IL-17F:Il17f | C | C | A | - | - | Immunity 30: 108-19 (2009) | |
IL-17A/F:Il17a/Il17f | C | A | A | - | - | Immunity 30: 108-19 (2009) | |
TNFα:Tnfa | - | C | C | - | - | Lab Invest 77: 647-58 (1997) | 3 |
CC chemokine receptor 8:Ccr8 | - | C | C | - | - | Int Immunol 27:169-81 (2015) | |
CXC chemokine receptor 4:Cxcr4 | - | C | C | - | - | Arthritis Res Ther 12: R188 (2010) | |
polymeric immunoglobulin receptor:Pigr | - | - | - | - | - | J Immunol 163: 5367-73 (1999) | 5 |
Melanocortin 2 receptor:Mc2r | - | C | - | - | - | Proc Natl Acad Sci USA 103: 18205-10 (2007) | |
βGlcNAcβ1,4-galactosyltransferase1:B4galt1 | C | - | - | - | - | EMBO J 16: 1850-7 (1997) | |
Protein tyrosine phospatase recepter typeδ:Ptprd | - | - | - | - | - | EMBO J 19: 2775-85 (2000) | 7 |
docking protein 7: Dok7 | C | - | - | - | - | Science 312:1802-5 (2006) | 6 |
Eph receptor A2:Epha2 | C | - | - | - | - | Mech Div 102: 95-102 (2001) | |
guanine nucleotide binding protein (G protein), β1:Gnb1 | C | C | - | - | - | Dev Dyn 239:1089-101 (2010) | |
EST gene 4933427D06Rik:4933427D06Rik | C | C | - | - | - | - |
transgenic mouse | Genetic background** | ||||||
---|---|---|---|---|---|---|---|
Strains | 129*B6 | C57BL/6J | BALB/cA | C3H/HeN | NOD | Reference | note |
Human T-cell Leukemia Virus type 1(pX) gene | - | C | - | C | - | Science 253: 1026-8 (1991) | 7 |
c-fms promoter/tax gene | - | - | - | C | - | J Immunol 162: 2956-63 (1999) | |
Human Immunodeficiency Virus (RT-) gene | - | C | - | C | - | AIDS 6: 1069-75 (1992) | |
CD4 promoter/vpr gene | - | - | - | C | - | Virology 285: 181-92 (2001) | |
CD4 promoter/human CD4 gene | - | - | - | C | - | J Virol 81:677-88 (2007) | |
metallothioneine promoter/Ifnb gene | - | - | - | C | - | EMBO J 7: 3757-62 (1988) | |
SAP promoter/RANKL | - | C | - | - | - | J Bone Miner Metab 20: 337-44 (2002) | 4 |
PGK promoter/neomycin phosphotransferase gene | - | - | - | C | - | - | |
CD34 promoter/Cre recombinase gene | C | - | - | - | - | - | 7 |
** mice were backcrossed more than 8 generations except for 129*B6 intercrossed mice
Additional permission from the following developers is required.- 1: Dr. M Aguet
- 2: Dr. M Kopf
- 3: Dr. K Sekikawa
- 4: Snow Brand Milk Products Co. Ltd.
- 5: You can obtain from Yakult Central Institute for Microbiological Research
- 6: Dr. Y Yamanashi
- 7: You can obtain from RIKEN BRC
Kubo Lab PI: Dr. Masato Kubo (raysolfc[at]rcai.riken.jp)
enhancer/promoter KO | Genetic background** | ||||||
---|---|---|---|---|---|---|---|
Strains | 129*B6 | C57BL/6J | BALB/cA | C3H/HeN | NOD | Reference | note |
pIl13 KO | |||||||
Il4 HS2 KO | |||||||
Il4 3’UTR KO | |||||||
Il4 HS4 KO | |||||||
Il4 CNS2 KO | |||||||
Il4 KO | |||||||
Il4r KO | |||||||
Ifng KO | |||||||
Il6 KO | |||||||
Il10 KO | |||||||
Il17a KO | |||||||
Il21 f/f | |||||||
Stat6 KO | |||||||
Stat3 f/f | |||||||
E4bp4 KO | |||||||
E4bp4 f/f | |||||||
Rbpj f/f | |||||||
Gata3 f/f | |||||||
Bcl6 f/f | |||||||
Rag1 KO | |||||||
Cd3 KO | |||||||
SOCS1 f/f | |||||||
SOCS3 f/f | |||||||
CIS1 Tg | |||||||
SOCS1 Tg | |||||||
SOCS3 Tg | |||||||
SOCS5 Tg | |||||||
OTII Tg |
cytokine reporter mice | Genetic background** | ||||||
---|---|---|---|---|---|---|---|
Strains | 129*B6 | C57BL/6J | BALB/cA | C3H/HeN | NOD | Reference | note |
IL-4GFP knock-in | |||||||
IL-4 hCD2 bac Tg | |||||||
IL-4 CNS2-GFP Tg | |||||||
IL-10 venus knock-in | |||||||
IL-13 tomato knock-in | |||||||
IL-21 hCD2 bac Tg | |||||||
IL-17GFP knock-in | |||||||
IFNγ venus bac Tg | |||||||
IFNβ Cherry bac Tg | |||||||
Mas-TRCK | |||||||
Bas-TRECK |
Kitamura Lab PI: Dr. Daisuke Kitamura (kitamura[at]rs.noda.tus.ac.jp)
Genetic background** | |||||||
---|---|---|---|---|---|---|---|
Strains | 129*B6 | C57BL/6J | BALB/cA | C3H/HeN | NOD | Reference | note |
muMT KO, IgH Cmu, neo. | B | Nature 350:423-6 (1991) | |||||
HS1 KO, neo, LacZ | C | EMBOJ 14:3664-78 (1995) | |||||
DNase g MT, KO, DNase g , neo | B | unpublished | |||||
BASH KO, KO BASH (BLNK/SLP-65), neo | B | Immunity 18:825-36 (2003) | |||||
RAG2 KO, KO, RAG2, neo | B | Cell 68:855-67 (1992) | |||||
PKCd KO, KO, PKCd (delta), neo | B | Nature 416:865-9 (2002) | |||||
Hy10, KO(KI)/Tg, IgH/kappa-Tg, VDJ9, kappa5 | B | Science 315:528-31 (2007) | |||||
VH B1-8Hi, KO (KI), IgH, VH B1-8, lox-P | B | Cell 90:1073-83 (1997) | |||||
CD19-Cre, KO (KI), CD19, neo, Cre, C57BL/6 | B | Nature 376:352-5 (1995) | |||||
IgG1-Cre, KO (KI), IgH Cgamma, Cre gene, lox-P | B | PNAS 103:7396-401 (2006) |
Goiizuka Lab PI : Dr. Ryo Goitsuka (ryogoi[at]rs.noda.tus.ac.jp)
Genetic background** | |||||||
---|---|---|---|---|---|---|---|
Strains | 129*B6 | C57BL/6J | BALB/cA | C3H/HeN | NOD | Reference | note |
Clnk KO (C57BL/6J):signal transduction | |||||||
Gpr141 KO (B6/129):GPCR | |||||||
Conditional knockout(floxed) | |||||||
Meis1(C57BL/6J):transcription factor | |||||||
pKnox1 (Prep1, Meis4)(C57BL/6J):transcription factor | |||||||
Cre driver, reporter(knockin) | |||||||
Tlx1-CreER-ires2-Venus (C57BL/6J):transcription factor |
Furuichi Lab PI: Dr. Teiichi Furuichi (tfuruichi[at]rs.tus.ac.jp)
Genetic background** | |||||||
---|---|---|---|---|---|---|---|
Original mouse lines | 129*B6 | C57BL/6J | BALB/cA | C3H/HeN | NOD | Reference | note |
1NM13 Tg: IP3R1 promoter (1kb)-nls-lacZ | |||||||
4NM1Tg: IP3R1 promoter (4kb)-nls-lacZ | |||||||
CAPS2 KO: Dense-core vesicle secretion-related protein | |||||||
CAPS2 dex3 KI: CAPS2 deletion of exon3 | |||||||
CAPS1 cKO: Dense-core vesicle secretion-related protein CAPS1 gene floxed mouse | |||||||
Mouse lines obtained from the public resources or collaborators | 129*B6 | C57BL/6J | BALB/cA | C3H/HeN | NOD | Reference | note |
reeler: Spontaneous mutant mouse (loss of reelin) provided | provided by RIKEN ( M. Ogawa) | ||||||
Cdf:Spontaneous mutant mouse (loss of Catna2) | provided by JAX | ||||||
KIAA1768 KO: RasGEF very-KIND gene | provided by RIKEN BRC (M. Nakayama, KAZUSA) | ||||||
p130Cas cKO: p130Cas floxed mouse | provided by RIKEN BRC (Dr. H. Honda, Hiroshima Univ) | ||||||
GAD67-GFP KI | provided by RIKEN BRC (Y. Yanagisawa, Gunma Univ) | ||||||
TH-GFP Tg: Tyrosine hydroxylase-GFP | provided by RIKEN BRC (K. Kobayashi, Fukushima Med Univ) | ||||||
YFP-H: YFP transgenic mouse H line | |||||||
CAG-Cre Tg: CAG promoter-Cre | |||||||
Emx1-Cre: Transcription factor Emx1-Cre KI | provided by RIKEN BRC (S. Itohara, RIKEN) | ||||||
Ptf1a-Cre: Transcription factor Ptf1a-Cre KI | provided by RIKEN BRC (M. Hoshino) | ||||||
CaMKII-Cre Tg: Protein kinase CaMKII-Cre | provided by RIKEN BRC (K. Mikoshiba, RIKEN) | ||||||
DBH-Cre: dopamine-beta-hydroxylase-Cre KI | provided by RIKEN BRC (K. Kobayashi, Fukushima Med Univ) | ||||||
Wnt1-Cre Tg | provided by JAX | ||||||
ROSA26-CreER Tg | provided by RIKEN BRC (M. Okabe, Osaka Univ) |
Higami LabPI: Dr. Yoshikazu Higami (higami[at]rs.tus.ac.jp)
Knockout | Genetic background** | ||||||
---|---|---|---|---|---|---|---|
Strains | 129*B6 | C57BL/6J | BALB/cA | C3H/HeN | NOD | Reference | note |
Srebp1c KO:transcription factor | B |