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研究業績Research Result

  • 岩倉 洋一郎Yoichiro Iwakura
    1. Silverpil, E., Wright, A. K., Hansson, M., Jirholt, P., Henningsson, L., Smith, M. E., Gordon, S. B., Iwakura, Y., Gjertsson, I., Glader, P., and Linden, A. Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation. Innate Immun., 19, 479-492 (2013).
    2. Nakatsuka, A., Wada, J., Iseda, I., Teshigawara, S., Higashio, K., Murakami, K., Kanzaki, M., Inoue, K., Terami, T., Katayama, A., Hida, K., Eguchi, J., Ogawa, D., Matsuki, Y., Hiramatsu, R., Yagita, H., Kakuta, S., Iwakura, Y., and Makino, H. Vaspin inhibits apoptosis of endothelial cells as a ligand for cell-surface GRP78/VDAC complex. Circ. Res., 112, 771-780 (2013).
    3. Kurimoto, E., Miyahara, N., Kanehiro, A., Waseda, K., Taniguchi, A., Ikeda, G., Koga, H., Nishimori, H., Tanimoto, Y., Kataoka, M., Iwakura, Y., Gelfand, E. W., and Tanimoto, M. IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice. Respir. Res., 14, 5 (2013).
    4. Lemaitre, P. H., Vokaer, B., Charbonnier, L. M., Iwakura, Y., Field, K. A., Estenne, M., Goldman, M., Leo, O., Remmelink, M., and Le Moine, A. Cyclosporine A drives a Th17- and Th2-mediated posttransplant obliterative airway disease. Am. J. Transplant., 13, 611-620 (2013).
    5. Kon, S., Minegishi, N., Tanabe, K., Watanabe, T., Funaki, T., Wong, W. F., Sakamoto, D., Higuchi, Y., Kiyonari, H., Asano, K., Iwakura. Y., Fukumoto, M., Osato, M., Sanada, M., Ogawa, S., Nakamura, T., and Satake, M. Smap 1 deficiency perturbs receptor trafficking and predisposes mice to myelodyspasia. J. Clin. Invest., 123, 1123-1137 (2013).
    6. Deroide, N., Li, X., Lerouet, D., Van Vre, E., Baker, L., Harrison, J., Poittevin, M. Masters, L., Nih, L., Margaill, I., Iwakura, Y., Ryffel, B., Pocard, M., Tedgui, A., Kubis, N., and Mallat, Z. MFGE8 inhibits inflammasome-induced IL-1? production and limits postischemic cerebral injury. J. Clin. Invest., 123, 1176-1181 (2013).
    7. Shepardson, K. M., Ngo, L. Y., Aimanianda, V., Latge, J.-P., Barker, B. M., Blosser, S. J., Iwakura, Y., Hohl, T. M., and Cramer, R. A. Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation. Microbe. Infect., 15, 259-269 (2013).
    8. Sugita, S., Kawazoe, Y., Imai, A., Usui, Y., Iwakura, Y., Isoda, K., Ito, M., and Mochizuki, M. Mature dendritic cell suppression by IL-1 receptor antagonist on retinal pigment epithelium cells. Invest .Ophthalmol. Vis. Sci., 54, 3240-3249 (2013).
    9. Miyake, Y., Toyonaga. K., Mori, D., Kakuta, S., Hoshino, Y., Oyamada, A., Yamada, H., Ono, K. I ., Suyama, M., Iwakura, Y., Yoshikai, Y., and Yamasaki, S. C-typte lectin MCL is an FcR?-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity, 38, 1050-1062 (2013).
    10. Katayama, M., Ohmura, K., Yukawa, N., Terao, C., Hashimoto, M., Yoshifuji, H., Kawabata, D., Fujii, T., Iwakura, Y., and Mimori, T. Neutrophils are essential as a source of IL-17 in the effector phase of arthritis. PLoS One, 8, e62231 (2013).
    11. Kuriya, G., Uchida, T., Akazawa, S., Kobayashi, M., Nakamura, K., Satoh, T., Horie, I., Kawasaki, E., Yamasaki, H., Yu, L., Iwakura, Y., Sasaki, H., Nagayama, Y., Kawakami, A., and Abiru, N. Double deficiency in IL-17 and IFN-? signaling significantly suppresses the development of diabetes in the NOD mouse. Diabetologia, 56, 1773-1780 (2013).
    12. Lukens, J. R., Vogel, P., Johnson, G. R., Kelliher, M. A., Iwakura, Y., Lamkanfi, M., and Kanneganti, T. D. RIP1-driven autoinflammation targets IL-1a independently of inflammasomes and RIP3. Nature, 498, 224-227 (2013).
    13. Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., Honda, K., Ishikawa, Y., Hara, E., and Ohtani, N. Obesity-induced gut microbial metabolite prootes liver cancer through senescence secretome. Nature, 499, 97-101 (2013).
    14. Ishida, H., Imai, T., Suzue, K., Hirai, M., Taniguchi, T., Yoshimura, A., Iwakura, Y., Okada, H., Suzuki, T., Shimokawa, C., and Hisaeda, H. IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages. Eur. J. Immunol., 43, 2696-2706 (2013).
    15. Funaki, T., Kon, S., Tanabe, K., Natsume, W., Sato, S., Shimizu, T., Yoshida, N., Wong, W. F., Ogura, A., Ogawa, T., Inoue, K., Ogonuki, N., Miki, H., Mochida. K., Endoh, K., Yomogida, K., Fukumoto, M., Horai, R., Iwakura, Y., Ito, C., Toshimori, K., Watanabe, T., and Satake, M. The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi-network and subsequent acrosome formation in spermaiogenesis. Mol. Biol. Cell, 24, 2633-2644 (2013).
    16. Al Shamsi, M., Shahin, A., Iwakura, Y., Lukic, M. L., and Mensah-Brown, E. P. Pam3CSK4 enhanced beta cell loss and diabetogenesis: The roles of IFN-gamma and IL-17. Clin. Immunol., 149, 86-96 (2013).
    17. Shigematsu, Y., Niwa, T., Rehnberg, E., Toyoda, T., Yoshida, S., Mori, A., Wakabayashi, M., Iwakura, Y., Ichinose, M., Kim, Y. J., and Ushijima, T. Interleukin-1b induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Lett., 340, 141-147 (2013).
    18. Lemaître, P. H., Vokaer, B., Charbonnier, L. M., Iwakura, Y., Estenne, M., Goldman, M., Leo, O., Remmelink, M., and Le Moine, A. IL-17A mediates early post-translpant lesions agter teterotopic trachea allotransplantation in mice. PLoS One, 8, e70236 (2013).
    19. Soeno, Y., Fujita, K., Kudo, T., Asagiri, M., Kakuta, S., Taya, Y., Shimazu, Y., Sato, K., Tanaka-Fujita, R., Kubo, S., Iwakura, Y., Nakamura, Y., Mori, S., and Aoba, T. Generation of a mouse model with down-regulated U50 snoRNA (SN0RD50) expression and its organ-specific phenotypic modulation. PLoS One, 26, 8: e72105 (2013).
    20. Freigang, S., Ampenberger, F., Weiss, A., Kanneganti, T. D., Iwakura, Y., Hersberger, M., and Kopf, M. Fatty acid-inudced mitochondrial uncoupling elicits inflammasome-independent IL-1a and sterile vascular inflammation in atherosclerosis. Nat. Immunol., 14, 1045-1053 (2013).
    21. Tanno, D., Akahori, Y., Toyama, M., Sato, K., Kudo, D., Abe, Y., Miyasaka, T., Yamamoto, H., Ishii, K., Kanno, E., Maruyama, R., Kushimoto, S., Iwakura, Y., and Kawakami, K. Involvement of Gr-1dull+ cellsin the production of TNF-a and IL-17 and exacerbated systemic inflammatory response caused by lipopolysaccharide. Inflammation, 2013 Sep 11. [Epub ahead of print]
    22. Chang, Y., Al-Alwan, L., Audusseau, S., Chouiali, F., Carlevaro-Fita, J., Iwakura, Y., Baglole, C. J., Eidelman, D. H., and Hamid, Q. Genetic deletion of IL-17A reduces cigarette smoke-induced inflammation and alveolar type II cell apoptosis. Am. J. Physiol. Lung Cell Mol. Physiol., 2013 Oct 4. [Epub ahead of print]
    23. Schmitt, E. G., Haribhai, D., Jeschke, J. C., Co, D. O., Ziegelbauer, J., Yan, K., Iwakura, Y., Mishra, M. K., Simpson, P., Salzman, N. H., and Williams, C. B. Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. J. Immunol., 191, 5460-5476 (2013).
    24. Kwon, S. J., Lee, G. T., Lee, J. H., Iwakura, Y., Kim, W. J., and Kim, I. Y. Mechanism of pro-tumorigenic effect of BMP-6: Neovascularizatioon involving tumor-associated macrophages and IL-1a. Prostate, 2013 Oct 8. doi: 10.1002/pros.22734. [Epub ahead of print]
    25. Do, J. S., Visperas, A., Freeman, M. L., Iwakura, Y., Oukka, M., and Min, B. Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and gd T cells. Immunol. Cell Biol., 92, 90-98 (2013).
    26. Miyasaka, T., Akahori, Y., Toyama, M., Miyamura, N., Ishii, K., Saijo, S., Iwakura, Y., Kinjo, Y., Miyazaki, Y., Oishi, K., and Kawakami, K. Dectin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine. PLoS One, 8, e78611 (2013).
    27. Murayama, M. A., Kakuta, S., Maruhashi, T., Shimizu, K., Seno, A., Kubo, S., Sato, N., Saijo, S., Hattori, M., and Iwakura, Y. CTRP3 plays an important role in the development of collagen-induced arthritis in mice. Biochem. Biophys. Res. Commun., 443, 42-48 (2013).
    28. Kim, H. Y., Lee, H. J., Chang, Y. J., Pichavant, M., Shore, S. A., Fitzgerald, K. A., Iwakura, Y., Israel, E., Bolger, K., Faul, J., Dekruyff, R. H., and Umetsu, D. T. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilliate obesity-associated airway hyperreactivity. Nat. Med., 20, 54-61 (2013).
    29. Takuya Tada, Motohiko Kadoki, Liu Yang, Kenzo Tokunaga, and Yoichiro Iwakura. Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells. Front. Microbiol., 4, 377. doi: 10.3389/fmicb.2013.00377 (2013).
    30. Ono, Y., Ogihara, Y., Saijo, S., Iwakura, Y., and Inoue, M. Evaluation of Kampo medicines used to treat rheumatoid arthritis in collagen-induced arthritic and pX transgenic mice. Mod. Rheumatol., 13, 50-56 (2013).
    31. Tanno, D., Akahori, Y., Toyama, M., Sato, K., Kudo, D., Abe, Y., Miyasaka, T., Yamamoto, H., Ishii, K., Kanno, E., Maruyama, R., Kushimoto, S., Iwakura, Y., and Kawakami, K. Involvement of Gr-1dull+ cellsin the production of TNF-? and IL-17 and exacerbated systemic inflammatory response caused by lipopolysaccharide. Inflammation, 37, 186-195 (2014).
    32. Kwon, S. J., Lee, G. T., Lee, J. H., Iwakura, Y., Kim, W. J., and Kim, I. Y. Mechanism of pro-tumorigenic effect of BMP-6: Neovascularizatioon involving tumor-associated macrophages and IL-1?. Prostate, 74, 121-133 (2014).
    33. Kagoya, Y., Yoshimi, A., Kataoka, K., Nakagawa, M., Kumano, K., Arai, S., Kobayashi, H., Saito, T., Iwakura, Y., and Kurokawa, M. Positive feedback between NF-?B and TNF-? promotes leukemia-initiating cell capacity. J. Clin. Invest., 124, 528-542 (2014).
    34. Lukens, J. R., Gross, J. M., Calabrese, C., Iwakura, Y., Lamkanfi, M., Vogel, P., and Kanneganti, T. D. Critical role for inflammasome-independent IL-1? production in osteomyelitis. Proc. Natl. Acad. Sci. U. S. A., 111, 1066-1071 (2014).
    35. Cassel, S. L., Janczy, J. R., Bing, X., Wilson, S. P., Olivier, A. K., Otero, J. E., Iwakura, Y., Shayakhmetov, D. M., Bassuk, A. G., Abu-Amer, Y., Brogden, K. A., Burns, T. L., Sutterwala, F. S., and Ferguson, P. J. Inflammasome-independent IL-1? mediates autoinflammatory diseases in Pstpip2-deficient mice. Proc. Natl. Acad. Sci. U. S. A., 111, 1072-1077 (2014).
    36. Song, X., Gao, H., Lin, Y., Yao, Y,. Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, and Qian Y. Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity, 40, 140-152 (2014).
    37. Ikeda, S., Saijo, S., Murayama, M. A., Shimizu, K., Akitsu, A., and Iwakura, Y. Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-?-induced Foxp3 expression. J. Immunol., 192, 1449-1458 (2014).
    38. Parsons, M. W., Li, L., Wallace, A. M., Lee, M. J., Katz, H. R., Fernandez, J. M., Saijo, S., Iwakura, Y., Austen, K. F., Kanaoka, Y., and Barrett, N. A. Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J. Immunol., 192, 1361-1371 (2014).
    39. Yamamoto, H., Nakamura, Y., Sato, K., Takahashi, Y., Nomura, T., Miyasaka, T., Ishii, K., Hara, H., Yamamoto, N., Kanno, E., Iwakura, Y., and Kawakami, K. Defect of CARD9 leads to impaired accululation of IFN-?-producing memory-phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans. Infect. Immun., 2014 Jan 27. [Epub ahead of print]
    40. Nakajima, S., Kitoh, A., Egawa, G., Natsuaki, Y., Nakamizo, S., Sagita, Moniaga, C., Otsuka, A., Honda, T., Hanakawa, S., Amano, W., Iwakura, Y., Nakae, S., Kubo, M., Miyachi, Y., and Kabashima, K. IL-17A as an inducer for Th2 immune responses in murine atopic dermatitits models. J. Invest. Dermatol., 2014 Jan 30. doi: 10.1038/jid.2014.51. [Epub ahead of print]
    41. Lai, C. Y., Yamazaki, S., Okabe, M., Suzuki, S., Maeyama, Y., Iimura, Y., Onodera. M., Kakuta, S., Iwakura, Y., Nojima, M., Otsu, M., and Nakauchi, H. Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation. Stem Cells, 2014 Feb 8. doi: 10.1002/stem.1670. [Epub ahead of print].
    42. Kobiyama. K., Aoshi, T., Narita, H., Kuroda, E., Hayashi, M., Tetsutani, K., Koyama, S., Mochizuki, S., Sakurai, K., Katakai, Y., Yasutomi, Y., Saijo, S., Iwakura, Y., Akira, S., Coban, C., and Ishii, K. J. Nonagonistic Dectin-1 ligand transforms GpG into a multiforms GpG into a multitask nanoparticlulate TLR9 agonist. Proc. Natl. Acad. Sci. U. S. A., 111, 3086-3091 (2014).
    43. Huang, G. J., Edwards, A., Tsai, C. Y., Lee, Y. S., Peng, L., Era, T., Hirabayashi, Y., Tsai, C. Y., Nishikawa, S., Iwakura, Y., Chen, S. J., and Flint, J. Ectopic cerebellar cell migration causes maldevelopment of purkinje cells and abnormal motor behavior in CXCR4 null mice. PLoS One, 9, e86471 (2014).
    44. Norimoto, A., Hirose, K., Iwata, A., Tamachi, T., Yokota, M., Takahashi, K., Saijo, S., Iwakura, Y., and Nakajima, H. Dectin-2 promotes house dust mite-induced Th2 and Th17 cell differentiation and allergic airway inflammation in mice. Am. J. Respir. Cell Mol. Biol., 2014 Mar 3. [Epub ahead of print]
    45. Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y., and Sun, J. Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in vial infection. J. Immunol., 2014 Mar 5. [Epub ahead of print] PMID: 24600029 [PubMed - as supplied by publisher]
    46. Benahmed, F., Chyou, S., Dasoveanu, D., Chen, J., Kumar, V., Iwakura, Y., and Lu, T. T. Multiple CD11c+ cells collaboratively express IL-1? to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth. J. Immunol., 2014 Mar 21. [Epub ahead of print]
    47. Inoue, Y., Shirasuna, K., Kimura, H., Usui, F., Kawashima, A., Karasawa, T., Tago, K., Dezaki, K., Nishimura, S., Sagara, J., Noda, T., Iwakura, Y., Tsutsui, H., Taniguchi, S., Yanagisawa, K., Yada, T., Yasuda, Y., and Takahashi, M. NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes. J. Immunol., 2014 Apr 2. [Epub ahead of print]
    48. Oshio, T., Kawashima, R., Kawamura, Y. I., Hagiwara, T., Mizutani, N., Okada, T., Otsubo, T., Inagaki-Ohara, K., Matsukawa, A., Haga, T., Kakuta, S., Iwakura, Y., Hosokawa, S., and Dohi, T. Chemokine receptor CCR8 is required for lipopolysassharide-triggered cytokine production in mouse peritoneal macrophages. PLoS One, 9, e94445 (2014).
    49. Akitsu, A., Kakuta, S., Saijo, S., and Iwakura, Y. Rag2-deficient IL-1 receptor antagonist-deficient mice are a novel colitis model in which innate lymphoid cell-derived IL-17 is involved in the pathogenesis. Exp. Anim., 63, 235-246 (2014).
    50. Akiho, H., Tokita, Y., Nakamura, K., Satoh, K., Nishiyama, M., Tsuchiya, N., Tsuchiya, K., Ohbuchi, K., Iwakura, Y., Ihara, E., Takayanagi, R., and Yamamoto, M. Involvement of IL-17A-induced hypercontractility of intestinal smooth muscle cells in persistent gut moter dysfunction. PLoS One, 9, e92960 (2014).
    51. Yasukawa, S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K., Yasuda, T., Natsuaki, Y., Mi-Ichi, F., Iizasa, E., Nakahara, T., Yamazaki, M., Kabashima, K., Iwakura, Y., Takai, T., Saito, T., Kurosaki, T., Malissen, B., Ohno, N., Furue, M., Yoshida, H., and Hara, H. An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. Nat. Commun., 5, 3755 (2014).
    52. Wang, X. H., Hu, L., Klein, J. D., Minakuchi, H., Wakino, S., Hosoya, K., Yoshifuji, A., Hayashi, K., Itoh, H., Tanaka, T., Higashijima, Y., Tanaka, S., Yamaguchi, J., Nangaku, M., Martino, F., Kielstein, J., Bang, C., Thum, T., Lorenzen, J., Stokman, G., El-Hachioui, M., Florquin, S., Pap, D., Himer, L., Szebeni, B., Sziksz, E., Riedl, Z., Iwakura, Y., Nagy, Szakal, D., Kis, E., Onody, A., Veres-Szekely, A., Javorszky, E., Koszegi, S., Fekete, A., A. Brandt, F., Reusz, G., Tulassay, T., and Vannay, A. Tissue injury and repair. Nephrol. Dial. Transplant., 29, Suppl 3:iii23-iii24. doi: 10.1093/ndt/gfu118 (2014).
    53. Sichelstiel, A., Yadava, K., Trompette, A., Salami, O., Iwakura, Y., Nicod, L. P., and Marsland, B. J. Targeting IL-1b and IL-17A driven inflammation during influenza-induced exacerbations of chronic lung inflammation. PLoS One, 9, e98440 (2014).
    54. Wu, L., Ong, S., Talor, M. V., Barin, J. G., Baldeviano, G. C, Kass D.A。, Bedja, D., Zhang, H., Sheikhm, A., Margolick, J. B., Iwakura, Y., Rose, N. R., and Ciháková, D. Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy. J. Exp. Med., 211, 1449-1464 (2014).
    55. Reber, L. L., Marichal, T., Sokolove, J., Starkl, P., Gaudenzio, N., Iwakura, Y., Karasuyama, H., Schwartz, L. B., Robinson, W. H., Tsai, M., and Galli, S. J. Mast cell-derived IL-1b contributes to uric acid crystal-induced acute arthritis in mice. Arthritis Rheumatol., 66, 2881-2891 (2014).
    56. Nikota, J. K., Shen, P., Morissette, M. C., Fernandes, K., Roos, A., Chu, D. K., Barra, N. G., Iwakura, Y., Kolbeck, R., Humbles, A. A., and Stampfli, M. R. Cigarette smoke primes the pulmonary environment to IL-1a/CXCR-2-dependent nontypeable haemophilus influenzae-exacerbated neutrophillia in mice. J. Immunol., 193, 3134-3145 (2014).
    57. Yamanaka, K., Nakanishim, T., Saito, H., Maruyamam, J., Isoda, K., Yokochi, A., Imanaka-Yoshida, K., Tsuda, K., Kakeda, M., Okamoto, R., Fujita, S., Iwakura, Y., Suzuki, N., Ito, M., Maruyama, K., Gabazza, E. C., Yoshida, T., Shimaoka, M., and Mizutani, H. Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease. Emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory disease. PLoS One, 9, e104479 (2014).
    58. Ito, K., Yamazaki, S., Yamamoto, R., Tajima, Y., Yanagida, A., Kobayashi, T., Kato-Itoh, M., Kakuta, S., Iwakura, Y., Nakauchi, H., and Kamiya, A. Gene targeting study reveals unexpected expression of brain expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice. J. Biol. Chem., 289, 29892-29911 (2014).
    59. Chiba, S., Ikushima, H., Ueki, H., Yanai, H., Kimura, Y., Hangai, S., Nishio, J., Negishi, H., Tamura, T., Saijo, S., Iwakura, Y., and Taniguchi T. Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. Elife, 3, e04177 (2014).
    60. Shimura, E., Shibui, A., Narushima, S., Nambu, A., Yamaguchi, S., Akitsu, A., Leonard, W. J., Iwakura, Y., Matsumoto, K., Suto, H., Okumura, K., Sudo, K., and Nakae, S. Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock. Biochem. Biophys. Res. Commun., 453, 1-6 (2014).
    61. Isoda, K., Akita, K., Isobe, S., Niida, T., Adachi, T., Iwakura, Y., and Daida, H. Interleukin-1 receptor antagonist originating from bone marrow-derived cells and non-bone marrow-derived cells helps to suppress arterial inflammation and reduce neointimal formation after injury. J. Atheroscler. Thromb., 21, 1208-1218 (2014).
    62. Natsuaki, Y., Egawa, G., Nakamizo, S., Ono, S., Hanakawa, S., Okada, T., Kusuba, N., Otsuka, A., Kitoh, A., Honda, T., Nakajima, S., Tsuchiya, S., Sugimoto, Y., Ishii, K. J , Tsutsui, H., Yagita, H., Iwakura, Y., Kubo, M., Ng, L. G., Hashimoto, T., Fuentes, J., Guttman-Yassky, E., Miyachi, Y., and Kabashima, K. Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin. Nat. Immunol., 15, 1064-1009 (2014).
    63. Ali, A., Zhu, X., Kwiecinski, J., Gjertsson, I., Lindholm, C., Iwakura, Y., Wang, X., Lycke, N., Josefsson, E., Pullerits, R., and Jin, T. Antibiotic-killed Staphyococcus aureus induces detructive arthritis in mice. Arthritis Rheumatol. 2014 Oct 9. doi: 10.1002/art.38902. [Epub ahead of print] PMID: 25302691 [PubMed - as supplied by publisher]
    64. Janczy, J. R., Ciraci, C., Haasken, S., Iwakura, Y., Olivier, A. K., Cassel, S. L., and Sutterwala, F. S. Immune complexes inhibit IL-1 secretion and inflammasome activation. J. Immunol., 193, 5190-5198 (2014).
    65. Yabe, R., Shimizu, K., Shimizu, S., Azechi, S., Choi, B. I., Sudo, K., Kubo, S., Nakae, S., Ishigame, H., Kakuta, S., and Iwakura, Y. CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes. Int. Immunol., 2014 Oct 25. pii: dxu098. [Epub ahead of print].
    66. Bourigault, M. L., Segueni, N., Rose, S., Court, N., Vacher, R., Vasseur, V., Erard, F., Le Bert, M., Garcia, I., Iwakura, Y., Jacobs, M., Ryffel, B., Quesniaux, V. F., Relative contribution of IL-1a, IL-1b and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG. Immun. Inflamm. Dis., 1, 47-62 (2014).
    67. Iizuka, M., Tsuboi, H., Matsuo, N., Asashima, H., Hirota, T., Kondo, Y., Iwakura, Y., Takahashi, S., Matsumoto, I., Sumida, T. Acruciall role of ROR-gamma-t in the development of spontaneous sialadenitis-like Sjogren’s syndrome. J. Immunol., 2014 Nov 19. pii: 1401118. [Epub ahead of print]
    68. Nakamura, Y., Sato, K., Yamamoto, H., Matsumura, K., Matsumoto, I., Nomura, T., Miyasaka, T., Ishii, K., Kanno, E., Tachi, M., Yamasaki, S., Saijo, S., Iwakura, Y., Kawakami, K. Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans. Infect. Immun., 2014 Nov 24. pii: IAI.02835-14. [Epub ahead of print]
    69. Seno, A., Maruhashi, T., Kaifu, T., Yabe, R., Fujikado, N., Ma, G., Ikarashi, T., Kakuta, S., and Iwakura, Y. Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor. Exp. Anim., 2014 Dec 15. [Epub ahead of print]
    70. Mizushina, Y., Shirasuna, K., Usui, F., Karasawa, T., Kawashima, A., Kimura, H., Kobayashi, M., Komada, T., Inoue, Y., Mato, N., Yamasawa, H., Latz, E., Iwakura, Y., Kasahara, T., Bando, M., Sugiyama, Y., and Takahashi, M. NLRP3 deficiency exacerbates hyperoxia-induced lethality through Stat3 signaling independently of interleukin-1b. J. Biol. Chem., 2014 Dec 29. pii: jbc.M114.603217. [Epub ahead of print]
    71. Jee, J., Bonnegarde-Bernard, A., Duverger, A., Iwakura, Y., Cormet-Boyaka, E., Martin, T. L., Steiner, H. E., Bachman, R. C., and Boyaka, P. N. Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization. Mucosal Immunol., 2015 Jan 7. doi: 10.1038/mi.2014.105. [Epub ahead of print]
    72. Oyoshi, M. K., Beaupré, J., Venturelli, N., Lewis, C. N., Iwakura, Y., Geha, R. S. Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus. J. Allergy Clin. Immunol., 2015 Jan 30. pii: S0091-6749(15)00003-2. doi: 10.1016/j.jaci.2014.12.1923. [Epub ahead of print]
    73. Shimizu, K., Nakajima, A., Sudo, K., Liu, Y., Mizoroki, A., Ikarashi, T., Horai, R., Kakuta, S., Watanabe, T., and Iwakura, Y. Interleukin-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting interleukin-1 signal on macrophages. J. Immunol., in press.
    74. Uryu, H., Hashimoto, D., Kato, K, Hayase, E., Matsuoka, S., Ogasawara, R., Takahashi, S., Maeda, Y., Iwasaki, H., Miyamoto, T., Saijo, S., Iwakura, Y., Hill, G. R., Akashi, K., and Teshima, T. a-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. Blood. 2015 Mar 4. pii: blood-2014-12-615781. [Epub ahead of print]
    75. Mai J, Nanayakkara G, Lopez-Pastrana J, Li X, Li YF, Wang X, Song A, Virtue A, Shao Y, Shan H, Liu F, Autieri MV, Kunapuli SP, Iwakura Y, Jiang X, Wang H, Yang XF. Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK) Pathway. J Biol Chem. (2016); 291:4939-54.
    76. Kawabe T, Suzuki N, Yamaki S, Sun SL, Asao A, Okuyama Y, So T, Iwakura Y, Ishii N. Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice. Eur J Immunol. (2016); 46:1119-31.
    77. Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Cappelletti M, Huppert SS, Iwakura Y, Dong C, Shanmukhappa SK, Divanovic S. Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. PLoS One. (2016); 11:e0149783.
    78. Lee EJ, Brown BR, Vance EE, Snow PE, Silver PB, Heinrichs D, Lin X, Iwakura Y, Wells CA, Caspi RR, Rosenzweig HL. Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye. J Immunol. (2016); 196:3148-58.
    79. Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y, Takayanagi H. IL-17-producing γδ T cells enhance bone regeneration. Nat Commun. (2016); 7:10928.
    80. Ciraci C, Janczy JR, Jain N, Haasken S, Pecli E Silva C, Benjamim CF, Sadler JJ, Olivier AK, Iwakura Y, Shayakhmetov DM, Sutterwala FS, Cassel SL. Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo. PLoS One. (2016); 11:e0151252.
    81. Javed N, Xue G, Lu A, Xing Y, Iwakura Y, Xiao H, Lecoeur H, Späth GF, Meng G. Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy. Cytokine. (2016); 81:101-8.
    82. Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X. T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Nat Immunol. (2016); 17:583-92.
    83. Shishikura M, Nakamura F, Yamashita N, Uetani N, Iwakura Y, Goshima Y. Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system. Brain Res. (2016); 1642:244-54.
    84. Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS. Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. Hypertension. (2016); 68:167-74.
    85. Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S. Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis. Innate Immun. (2016); 22:316-24.
    86. Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA. Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity. J Immunol. (2016); 197:278-87.
    87. Masamoto Y, Arai S, Sato T, Yoshimi A, Kubota N, Takamoto I, Iwakura Y, Yoshimura A, Kadowaki T, Kurokawa M. Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation. Immunity. (2016); 44:1422-33.
    88. Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N. Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells. J Biol Chem. (2016); 291:17629-38.
    89. Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y. IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression. Cancer Sci. (2016); 107:1206-14.
    90. Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K. The potential for repositioning antithyroid agents as antiasthma drugs. J Allergy Clin Immunol. (2016); 138:1458-1461.
    91. Niu X, Liu W, Wang Y, Liu X, Zhang H, Li Z, Li H, Iwakura Y, Deng W. IL-17A exacerbates cisplatin-based resistance of OVCA via upregulating the expression of ABCG2 and MDR1 through Gli1-mediated Hh signaling. Oncotarget. (2016); doi: 10.18632/oncotarget.10655.
    92. Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY. Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713-2722; DOI: 10.2337/db05-1430. Diabetes. (2016); 65:2462.
    93. Huang Y, Matsumura Y, Hatano S, Noguchi N, Murakami T, Iwakura Y, Sun X, Ohara N, Yoshikai Y. IL-21 inhibits IL-17A-producing γδ T-cell response after infection with Bacillus Calmette-Guérin via induction of apoptosis. Innate Immun. (2016); 22:588-597.
    94. Murakami T, Hatano S, Yamada H, Iwakura Y, Yoshikai Y. Two Types of Interleukin 17A-Producing γδ T Cells in Protection Against Pulmonary Infection With Klebsiella pneumoniae. J Infect Dis. (2016); 214:1752-1761.
    95. Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M. Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells. Stem Cells. (2016); doi: 10.1002/stem.2524.
    96. Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H. Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells. J Immunol. (2017); 198:61-70.
    97. Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T. The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis. Proc Natl Acad Sci U S A. (2016); 113:14097-14102.
    98. Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G. Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection. Immun Inflamm Dis. (2016); 4:401-412.
    99. Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ. Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation. Immunity. (2016); 45:1299-1310.
    100. Inoue SI, Niikura M, Asahi H, Iwakura Y, Kawakami Y, Kobayashi F. Preferentially expanding Vγ1+ γδ T cells are associated with protective immunity against Plasmodium infection in mice. Eur J Immunol. (2016); doi: 10.1002/eji.201646699.
    101. Kaifu, T., and Iwakura, Y. Dendritic cell immunoreceptor (DCIR): An ITIM-harboring C-type lectin receptor. In “C-Type Lectin Receptor in Immunity”, (ed. Sho Yamasaki) (ISBN: 978-4-431-56013-5, DOI: 10.1007/978-4-431-56015-9_7), Springer Japan, p. 101-113 (2016).
    102. Takagi N, Kawakami K, Kanno E, Tanno H, Takeda A, Ishii K, Imai Y, Iwakura Y, Tachi M. IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin. Exp Dermatol. (2017); 26:137-144.
    103. Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y, Inaba K, Takahara K. Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice. Eur J Immunol. (2017); doi: 10.1002/eji.201646814.
    104. Akitsu A, Iwakura Y. Isolation of joint-infiltrating cells. Bio-Protocol. (in press, DOI: https://doi.org/10.21769/BioPtotoc.1911) (2017)
    105. Furukawa, K., Fuse, I., Iwakura, Y., Sotoyama, H., Hanyu, O., Nawa, H., Sone, H., and Takei, N. Advanced glycation end products induce brain-derived neurotrophic factor release from human plateltets through the Src-family kinase activation. Cardiovasc. Diabetol., (2017); 16, 20. doi: 10.1186/s12933-017-0505-y.
    106. Yan, X., Zhang, H., Fan, Q., Hu, J., Tao, R., Chen, Q., Iwakura, Y., Shen, W., Lu, L., Zhang, Q., and Zhang, R. Dectin-2 deficiency modulates Th1 differentiation and improves wound healing after myocardial infarction. Circ. Res., (2017 Feb 13). pii: CIRCRESAHA.116.310260. doi:10.1161/CIRCRESAHA.116.310260. [Epub ahead of print]
  • 久保 允人Masato Kubo
    1. Firth, M.A., Madera,S., Aimee M. Beaulieu, A.M., Gasteiger,G., Schluns, K.S., Kubo, M, Rothman, P.B., Vivier, E., and Sun, J.C.;Nfil3-independent lineage maintenance of natural killer cells. J.Exp.Med. in press
    2. Noti, M., Tait, E.D., Wojno, T., Kim, B. S. Siracusa, M.C., Giacomin, P.R., Nair, M.G., Kubo, M., Alain J. Benitez, A.J., Ruymann, K.R., Comeau, M.R., Cianferoni, A., Wang, M., Spergel, J.S., and Artis, D., Heterogeneous immunologic pathways underlie the pathogenesis of the allergic march. Nature Medicine 2013,19(8):1005-13,
    3. Matsunaga, A., Fukuyama, S., Okuno, T., Sasaki, F., Matsunobu, T., Asai, Y., Matsumoto, K., Saeki, K., Oike, M., Sadamura, Y., Machida, K., Nakanishi, Y., Kubo, M., Yokomizo, T., Inoue, H., Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia, The FASEB Journal 2013, 27(8):3306-14
    4. Kubo, M., Therapeutic hope for psoriasis offered by SOCS mimetic peptide. Eur. J. Immunol. 2013, 43(7):1702-5
    5. Furusawa, J., Moro, K., Motomura, Y., Okamoto, K., Zhu, J., Takayanagi, H., Kubo, M., Koyasu, S., Critical role of p38 and GATA3 in natural helper cell function. J. Immunol. 2013, 191(4):1818-26
    6. Otsuka, A., Nakajima S, Kubo M, Egawa G, Honda T, Kitoh A, Nomura T, Hanakawa S, Sagita Moniaga C, Kim B, Matsuoka S, Watanabe T, Miyachi Y, Kabashima, K., : Basophils are required for the induction of Th2 immunity to haptens and peptide antigens. Nature Communication 2013, 4:1738.
    7. Nakajima, S., Kitoh, A., Egawa, G., Natsuaki, Y., Nakamizo, S., Moniaga, C.A., Otsuka, A., Honda, T., Hanakawa, S., Amano, W., Iwakura, Y., Nakae, S., Kubo, M., Miyachi,Y., and Kabashima, K.: IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models Journal of Investigative Dermatology 134(8):2122-30 2014
    8. Kurashima, Y., Amiya, T., Fujisawa, K., Shibata, N., Suzuki, Y., Kogure, Y., Hashimoto, E., Otsuka, A., Kabashima, K., Sato, S., Kubo, M., Yokota, Y., Akira, S., Miyake, K., Kunisawa, J., and Kiyono, H. The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrierhomeostasis. Immunity 40 (4): 530-541, 2014
    9. Nakashima, C., Otsuka, A., Kitoh, A., Honda,T., Egawa,G., Nakajima,S., Nakamizo,S., Arita, M., Kubo, M., Miyachi,Y., and Kabashima, K.: Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis. Journal of Allergy and Clinical Immunology134(1):100-7..2014.
    10. Motomura, Y., Morita, H., Moro, K., Nakae, S., Artis, D., Koyasu,S., Kubo, M. Basophil-derived IL-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. Immunity 40 (5): 758–771, 2014
    11. Noti, M., Kim, B.S., Siracusa, M.C., Rak, G.D., Kubo, M., Moghaddam, A.E., Sattentau, Q.A., Comeau, M.R., Spergel, J.M., and Artis, D.,; Exposure to food allergens through inflamed 1 skin promotes intestinal food allergy via the TSLP-basophil axis. Journal of Allergy and Clinical Immunology 133(5):1390-9, 2014
    12. Moriyama, S., Takahashi, N., Green, J.A., Kubo, M., Cyster J.G. and Okada, T., Sphingosine-1-phosphate receptor 2 controls follicular helper T cell localization to support germinal center response. J.Exp.Med. 211(7), 1297-1305, 2014
    13. Wataru Ise, Takeshi Inoue, James B McLachlan, Kohei Kometani, Kubo, M., Takaharu Okada and Tomohiro Kurosaki : Memory B cells contribute to rapid Bcl6 expression of memory TFH cells. Proc. Natl. Acad. Sci. U.S.A. 111(32):11792-7 2014
    14. Brian S. Kim, Mark C. Siracusa, Kelvin Wang, Steven A. Saenz, Kubo, M., and David Artis: Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin. J. Immunol. 193(7):3717-25, 2014
    15. Natsuaki, Y., Egawa, G., Nakamizo, S., Hanakawa, S., Ono, S., Okada, T., Kusuba, N., Otsuka, A., Kitoh, A., Honda, T., Nakajima, S., Tsuchiya, S., Sugimoto, Y., Ishii, J. K., Tsutsui, H., Yagita, H., Iwakura, Y., Kubo, M., Hashimoto, T., Fuentes, J., Guttman-Yassky, E., Miyachi, Y., and Kabashima, K., : Perivascular leukocyte cluster: an essential structure for efficient effector T cell activation in the skin. Nature Immunology 15(11):1064-9, 2014
    16. Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl4, Véronique Braud, Barbara Kee, Hugh Brady, Mark C.Coles, Christian Vosshenrich, Kubo, M., James P. Di Santo and Henrique Veiga-Fernandes:NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors. Cell Report in press
    17. Nakano, N., Nishiyama, C., Yagita, H., Hara, M., Motomura, Y., Kubo, M., Okumura, K., and Ogawa, H., Notch signaling enhances FceRI-mediated cytokine production by mast cells through direct and indirect mechanisms. J. Immunol. in press
    18. Ugajin, T., Nishida, K., Yamasaki, S., Suzuki, J., Mita, M., Kubo, M., Yokozeki, H., Hirano, T., : Zinc-binding metallothioneins are key modulators of IL-4 production by basophils Molecular Immunology in press
    19. Takeuchi, A., Badr, M.E.S., Miyauchi, K., Ishihara, C. Onishi, R., Guo, Z., Sasaki, Y., Ike, H., Takumi, A., Tsuji, N., Murakami, Y., Katakai,T., Kubo, M., and Saito, T., CRTAM determines the CD4+ cytotoxic T lymphocyte lineage, J. Exp. Med. 213:123-138, 2016
    20. Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo, M., Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H.: Jak1 tyrosine kinase hyperactivation induces spontaneous progressive pruritic dermatitis. J. Clin. Invest. 126(6):2064–2076. 2016
    21. Miyauchi, K., Sugimoto-Ishige, A., Harada, Y., Adachi, Y., Usami, Y., Kaji, T., Hasegawa, H., Watanabe, T., Hijikata, A., Fukuyama, S., Maemura, T., Ohara, O., Kawaoka, Y., Takahashi, Y., Takemori, T., and Kubo, M.,: Protective neutralizing influenza antibody response in the absence of T follicular helper cells. Nature Immunology 17(12), p1447-1458, 2016
    22. Elisa Domínguez-Hüttinger, Panayiotis Christodoulides, Kosuke Miyauchi, Alan D Irvine, Mariko Okada-Hatakeyama, Kubo, M., and Reiko J Tanaka, Mathematical Modeling of Atopic Dermatitis Reveals “Double switch” Mechanisms Underlying Four Common Disease Phenotypes, Journal of Allergy and Clinical Immunology pii:S0091-6749 (16) 31433-6, 2016
    23. Satoshi Tsurusaki, Satoko Tahara-Hanaoka, Shota Miyake, Shohei Shibagaki, Masamichi Imai, Shiro Shibayama, Kubo, M., Akira Shibuya: Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis. Int.Immunol. 28(12):605-609, 2016
    24. Shirota, H., Klinman, D.M., Ito, SE., Ito, H., Kubo, M.,, Ishioka, C.,: IL4 from T follicular helper cells downregulates antitumor immunity. Cancer Immunology Research, 5(1):61-71, 2017
    25. Maryam Hussain, Loïc Borcard, Kevin P. Walsh, Maria Pena Rodriguez, Kubo, M., Christoph Mueller, Brian S. Kim, David Artis, Mario Noti,; Basophil-derived interleukin-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy. Journal of Allergy and Clinical Immunology, in press, 2017
    26. Kubo, M., T follicular helper and Th2 cells in allergic responses. Allergology International invited review 2017
    27. Kubo, M., Innate and adaptive type 2 immunity in lung allergic inflammation. Immunological Review invited review 2017
  • 北村 大介Daisuke Kitamura
    1. Moutai, T., Yamana, H., Nojima, T. and Kitamura, D. A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. PLoS One 9: e92732, 2014.
    2. Fukao, S., Haniuda, K., Nojima, T., Takai, T. and Kitamura, D. Gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells. J. Immunol. 193: 635-644, 2014.
    3. Wu, L., Parekh, V.V., Hsiao, J., Kitamura, D. and Van Kaer, L. Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance. Proc. Natl. Acad. Sci. USA 111: E4638-E4647, 2014.
    4. Kitabatake, M., Soma, M., Zhang, T., Kuwahara, K., Fukushima, Y., Nojima, T., Kitamura, D. and Sakaguchi, N. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. J. Immunol. 194:1480-1488, 2015.
    5. Webb, L.M., Datta, P., Bell, S.E., Kitamura, D., Turner, M. and Butcher, G.W. GIMAP1 is essential for the survival of naive and activated B cells in vivo. J. Immunol. 196: 207-216, 2016.
    6. Kuraoka, M., Schmidt, A.G., Nojima, T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S.C., Kepler, T.B. and Kelsoe, G. Complex antigens drive permissive clonal selection in germinal centers. Immunity 44: 542-552, 2016.
    7. Domeier, P.P., Chodisetti, S.B., Soni, C., Schell, S.L., Elias, M.J., Wong, E.B., Cooper, T.K., Kitamura, D. and Rahman, Z.S. IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J. Exp. Med. 213: 715-732, 2016.
    8. Haniuda, K., Fukao, S., Kodama, T., Hasegawa, H. and Kitamura, D. Autonomous membrane IgE signaling prevents IgE-memory formation. Nat. Immunol. 17: 1109-1117, 2016.
    9. Koyama, R., Arai, T., Kijima, M., Sato, S., Miura, S., Yuasa, M., Kitamura, D., Mizuta, R. DNase γ, DNase I and caspase-activated DNase cooperate to degrade dead cells. Genes Cells 21:1150-1163, 2016.
    10. Lee, P., Zhu, Z., Hachmann, J., Nojima, T., Kitamura, D., Salvesen, G. and Rickert, R.C. Differing requirements for MALT1 function in peripheral B cell survival and differentiation. J. Immunol. 198:1066-1080, 2017.
  • 中野 直子Naoko Nakano
    1. Shibuya K., and Nakano N. Interleukin-2 drives immature double negative thymocytes into gd T cells expressing Foxp3 on a stromal cell line in vitro. Biochem. Biophys. Res. Commn. 452: 912-919, 2014
  • 小園 晴生Haruo Kozono
    1. Haruo Kozono, Yufuku Matsushita, Naoki Ogawa, Yuko Kozono, Toshihiro Miyabe, Hiroshi Sekiguchi, Kouhei Ichiyanagi, Noriaki Okimoto, Makoto Taiji, Osami Kanagawa, Yuji C. Sasaki: Single Molecular Motions of MHC Class II Rely on Bound Peptides. Biophysical journal 108: 350-9. (2015)
    2. Yuko Kozono, Ryuma Tanizawa, Sae Sato, Naoki Ogawa, Hiroshi Sekiguchi, Satoshi Ishido, Yuji C. Sasaki, Osami Kanagawa, Haruo Kozono: Peptides dependent ubiquitination of major histocompatibility complex class II protein. in prep.
  • 小川 修平Syuhei Ogawa
    1. Shimizu R., Umezawa M., Okamoto S., Onoda A., Uchiyama M., Tachibana K., Watanabe S., Ogawa S., Abe R., Takeda K. Effect of maternal exposure to carbon black nanoparticle during early gestation on the splenic phenotype of neonatal mouse. J. Toxicol. Sci. 39, 571-578 (2014).
    2. Aoki, S., Tanaka, T., Tsukimoto, M., Mori, N., Nishino, K., Tanamachi, K., Abe, R., Suzuki, T., Ogawa, S., Wakamatsu, E., Horie, K., Sakurai, Y., Tanaka, H., and Ono, K.: Establishment of Innovative Combination Therapy with Boron Neutron Capture Therapy and Immune Therapy, Kyoto Univ. Research Reactor (KUR) Pregress Report (2014).
    3. Akieda, Y., Wakamatsu, E., Nakamura, T., Ishida, Y., Ogawa, S., and Abe, R.: Defects in regulatory T cells due to CD28-deficiency induce a qualitative change of allogeneic immune response in chronic graft-versus-host disease. J. Immunol., in press (2015).
    4. Ohtsuka, S., Ogawa, S., Wakamatsu, E., and Abe, R. Cell cycle arrest caused by MEK/ERK signaling is a mechanism for suppressing growth of antigen-hyperstimulated effector T cells. Int. Immunol. 28(11):547-557 (2016)
    5. Inaba, S., Numoto, N., Ogawa, S., Morii, H., Ikura, T., Abe, R., Ito, N. and Oda, M. Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the SH2 Domains of Three Adaptor Proteins. J. Biol. Chem. 292(3):1052-1060 (2017)
  • 月本 光俊Mitsutoshi Tsukimoto
    1. Toki Y, Takenouchi T, Harada H, Tanuma SI, Kitani H, Kojima S, Tsukimoto M. Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death. Biochem Biophys Res Commun. (2015) in press
    2. Kawano A, Hayakawa A, Kojima S, Tsukimoto M, Sakamoto H, Purinergic signaling mediates oxidative stress in UVA-exposed THP-1 cells. Toxicology reports (2015) in press
    3. Kawakami Y, Murashima YL, Tsukimoto M, Baba A, Miyatake C, Okazaki T, Takagi A, Koizumi S, Kojima S, Fujino O, Itoh Y. Significance of glutathione-mediated scavenger potency in the development of seizure susceptibility in the EL mouse brain. Journal of Pediatric Epilepsy (2015) in press
    4. Takai E, Tsukimoto M, Harada H, Kojima S. Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells. Purinergic Signal. 2014 Sep;10(3):487-97.
    5. Takenouchi T, Suzuki S, Shinkai H, Tsukimoto M, Sato M, Uenishi H, Kitani H. Extracellular ATP does not induce P2X7 receptor-dependent responses in cultured renal- and liver-derived swine macrophages. Results Immunol. (2014) 4:62-7.
    6. Ishimaru M, Yusuke N, Tsukimoto M, Harada H, Takenouchi T, Kitani H, Kojima S. Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells. J Toxicol Sci. (2014) 39(3):413-23.
    7. Nagakura C, Negishi Y, Tsukimoto M, Itou S, Kondo T, Takeda K, Kojima S. Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes. Toxicology. (2014) 1;322:61-8.
    8. Kojima S, Negishi Y, Tsukimoto M, Takenouchi T, Kitani H, Takeda K. Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle. Toxicology. (2014) 3;321:13-20.
    9. Kaji W, Tanaka S, Tsukimoto M, Kojima S. Adenosine A(2B) receptor antagonist PSB603 suppresses tumor growth and metastasis by inhibiting induction of regulatory T cells. J Toxicol Sci. (2014) 39(2):191-8.
    10. Ide S, Nishimaki N, Tsukimoto M, Kojima S. Purine receptor P2Y6 mediates cellular response to γ-ray-induced DNA damage. J Toxicol Sci. (2014) 39(1):15-23.
    11. Nishino K, Tanamachi K, Nakanishi Y, Ide S, Kojima S, Tanuma S, Tsukimoto M., Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells. Biol Pharm Bull. (2016) 39(7):1224-30.
    12. Nakanishi K, Tsukimoto M, Tanuma S, Takeda K, Kojima S., Silica nanoparticles activate purinergic signaling via P2X7 receptor in dendritic cells, leading to production of pro-inflammatory cytokines. Toxicol In Vitro. (2016) 35:202-11.
    13. Ninomiya Y, Tanuma SI, Tsukimoto M., Differences in the effects of four TRPV1 channel antagonists on lipopolysaccharide-induced cytokine production and COX-2 expression in murine macrophages. Biochem Biophys Res Commun. (2017) (in press)
  • 深井 文雄Fumio Fukai
    1. Tenascin-C-derived Peptide TNIIIA2 Highly Enhances Cell Survival and PDGF-dependent Cell Proliferation through Potentiated and Sustained Activation of Integrin a5b1.Tanaka R., Seki, Y., Kamiya S., Saito Y., Fujita, M., Okutsu, H., Iyoda T., Takai, T., Owaki T., Yajima H., Taira J., Hayashi R., Kodama, H., Matsunaga, T., and Fukai F. J Biol Chem. i289:17699−17708, 2014
    2. A novel mechanism underlying the basic defensive response of macrophages against Mycobacterium infection. Iyoda T., Takada, M., Fukatsu, K., Kumokoshi, S., Fujisawa, T., Shimada, T.,Shimokawa, N., Matsunaga, T., Makino, K., Doi, N., Terada, H., and Fukai, F. J. Immnunol. 192: 4254-4262, 2014
    3. Cell regulation through adhesion to the extracellular matrix via adhesion molecule, integrins —Therapeutic application of integrin activation-modulating peptides—Matsunaga T., Iyoda T. and Fukai F. in Colloid and Interface Science in Pharmaceutical Research and Development. Ed. Ohshima H., in press Elsevier 2013
    4. Takagi, R., Kobayashi , S., Yamato, M, Owaki, T., Kasai, Y., Takeda, N., Fukai, F., Eguchi, S., and Okano, T. How to prevent contamination with Candida albicans during the fabrication of transplantable pral mucosal epithelial cell sheets. Regenerative Therapy 29, 1-4, (2015)
    5. Iyoda, T., Kazama, M., Fuikai, F., Role of the Tenascin-C-Derived Peptide TNIIIA2 in the Formation of Atherosclerotic Foam Cell. Peptide Science 2014, 61-64, (2015).
    6. Maeda, M., Kanai, N., Kobayashi, S., Hosoi, T., Takagi, R., Yamato, M., Eguchi, S., Fukai, F., Okano, T., Endoscopic cell sheet transplantation device developed by using a 3-dimensional printer and its feasibility evaluation in a porcine model. GASTROINTESTINAL ENDOSCOPY, 82, 147 – 152 (2015)
    7. Kobayashi S, Kanai N, Tanaka N, Maeda M, Hosoi T, Fukai F, Eguchi S, Yamato M., Transplantation of epidermal cell sheets by endoscopic balloon dilatation to avoid esophageal re-strictures: initial experience in a porcine model., Endosc Int Open. 4(11):E1116-E1123.(2016)
    8. Kuga A., Imaizumi T., Iyoda T, & Fukai F., Membrane Expression of Eukaryotic Protein Elongation Factor (eEF) 1A and its Physiological Role, Peptide Science, 2015: 235 – 238 (2016)
    9. Onuma W, Tomono S, Miyamoto S, Fujii G, Hamoya T, Fujimoto K, Miyoshi N, Fukai F, Wakabayashi K, Mutoh M., Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice. Oncotarget. 7(8):8640-52 (2016)
    10. Iyoda T., & Fukai F., Promotion of Macrophage Foam Cell Formation by the Peptide Derived from Tenascin-C, Peptide Science, 2015: 203 – 206 (2016)
    11. Imaizumi T., Kuga A., Iyoda T., & Fukai F., Participation of Membrane-Type eEF1A in Migration, Invasion, and Metastasis of Tumor Cells, Peptide Science, 2015:193 – 196, (2016)
    12. Iyoda T, Nagamine Y, Nakane Y, Tokita Y, Akari S, Otsuka K, Fujita M, Itagaki K, Takizawa Y, Orita H, Owaki T, Taira J, Hayashi R, Kodama H, & Fukai F., Coadministration of the FNIII14 Peptide Synergistically Augments the Anti-Cancer Activity of Chemotherapeutic Drugs by Activating Pro-Apoptotic Bim, PLoS One 11(9), eO162525 (2016)
    13. Suzuki H, Sasada M, Kamiya S, Ito Y, Watanabe H, Okada Y, Ishibashi K, Iyoda T, Yanaka A, & Fukai F., The Promoting Effect of the Extracellular Matrix Peptide TNIIIA2 Derived from Tenascin-C in Colon Cancer Cell Infiltration., Int J Mol Sci. 18(1). pii: E181. (2017)
  • 辻 孝Takashi Tsuji
    1. Ogawa M, Oshima M, Imamura A, Sekine Y, Ishida K, Yamashita K, Nakajima K, Hirayama M, Tachikawa T, Tsuji T., Functional salivary gland regeneration by transplantation of a bioengineered organ germ. Nature Communications 4:2498. doi: 10.1038/ncomms3498, 2013.
    2. Hirayama M, Ogawa M, Oshima M, Sekine Y, Ishida K, Yamashita K, Ikeda K, Shimmura S, Kawakita T, Tsubota K, Tsuji T. Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ. Nature Communications 4:2498. doi: 10.1038/ncomms3497, 2013.
    3. Kentaro Ishida, Yohei Yuge, Mai Hanaoka, Masato Yasukawa, Yoko Minami, Miho Ogawa, Ko-hei Masumoto, Yasufumi Shigeyoshi, Masahiro Saito, Takashi Tsuji, Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression, Genes to Cells, 18(8), 660-671, 2013
    4. Masato Yasukawa, Kentaro Ishida, Yohei Yuge, Mai Hanaoka, Yoko Minami, Miho Ogawa, Takashi Sasaki, Masahiro Saito, Takashi Tsuji, Dpysl4 Is Involved in Tooth Germ Morphogenesis through Growth Regulation, Polarization and Differentiation of Dental Epithelial Cells. International Journal of Biological Sciences 9(4),382-390, 2013
    5. Jun Ishikawa, Masamitsu Oshima, Fumitaka Iwasaki, Ryoji Suzuki, Joonhong Park, Kazuhisa Nakao, Yuki Matsuzawa-Adachi, Taro Mizutsuki, Ayaka Kobayashi, Yuta Abe, Eiji Kobayashi, Katsunari Tezuka & Takashi Tsuji, Hypothermic temperature effects on organ survival and restoration, Scientific Reports, in Press.
    6. Sara Yajima-Himuro, Masamitsu Oshima, Gou Yamamoto, Miho Ogawa, Madoka Furuya, Junichi Tanaka, Kousuke Nishii, Kenji Mishima, Tetsuhiko Tachikawa, Takashi Tsuji & Matsuo Yamamoto, The junctional epithelium originates from the odontogenic epithelium of an erupted tooth. Scientific Reports 4:4867. DOI: 10.1038/srep0486, 2014
    7. Masamitsu Oshima, Kaoru Inoue, Kei Nakajima, Tetsuhiko Tachikawa, Hiromichi Yamazaki,Tomohide Isobe, Ayaka Sugawara, Miho Ogawa, Chie Tanaka, Masahiro Saito, Shohei Kasugai,Teruko Takano-Yamamoto, Takashi Inoue, Katsunari Tezuka, Takuo Kuboki, Akira Yamaguchi & Takashi Tsuji, Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy. Scientific Reports 4:6044. DOI: 10.1038/srep06044, 2014
    8. Miho Ogawa, Kentaro Yamashitac, Minori Niikurad, Kei Nakajima, Koh-ei Toyoshima, Masamitsu Oshima, Takashi Tsuji Saliva secretion in engrafted mouse bioengineered salivary glands using taste stimulation, Journal of Prosthodontic Research 58(1):17-25, Doi: 10.1016/j.jpor.2013.12.001, 2014.
    9. Ritsuko Morita, Miho Kihira, Yousuke Nakatsu, Yohei Nomoto, Miho Ogawa, Kazumasa Ohashi, Kensaku Mizuno, Tetsuhiko Tachikawa, Yukitaka Ishimoto, Yoshihiro Morishita, and Takashi Tsuji, Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations, PLoS One, 11(9):e0161336, 2016.
    10. Kei Nakajima, Masamitsu Oshima, Naomi Yamamoto, Chie Tanaka, Ryosuke Koitabashi, Takashi Inoue and Takashi Tsuji, Development of a Functional Biohybrid Implant Formed from Periodontal Tissue Utilizing Bioengineering Technology. Tissue Engineering Part A, 22(17-18): 1108-1015, 2016.
    11. Ryoji Takagi, Junko Ishimaru, Ayaka Sugawara, Koh-ei Toyoshima, Kentaro Ishida, Miho Ogawa, Kei Sakakibara, Kyosuke Asakawa, Akitoshi Kashiwakura, Masamitsu Oshima, Ryohei Minamide, Akio Sato, Toshihiro Yoshitake, Akira Takeda, Hiroshi Egusa and Takashi Tsuji, Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model, Science Advances, 2(4):e1500887, doi: 10.1126/sciadv.1500887, 2016.
  • 斎藤 正寛Masahiro Saito
    1. Aino M, Nishida E, Fujieda Y, Orimoto A, Mitani A, Noguchi T, Makino H, Murakami S, Umezawa A, Yoneda T, Saito M. Isolation and characterization of the human immature osteoblast culture system from the alveolar bones of aged donors for bone regeneration therapy. Expert Opin Biol Ther. 2014 Dec;14(12):1731-44. doi: 10.1517/14712598.2014.960387. Epub 2014 Sep 22
    2. Oshima M, Inoue K, Nakajima K, Tachikawa T, Yamazaki H, Isobe T, Sugawara A, Ogawa M, Tanaka C, Saito M, Kasugai S, Takano-Yamamoto T, Inoue T, Tezuka K, Kuboki T, Yamaguchi A, Tsuji T. Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy. Sci Rep. 2014 Aug 13;4:6044. doi: 10.1038/srep06044.
    3. Umeyama K, Watanabe K, Watanabe M, Horiuchi K, Nakano K, Kitashiro M, Matsunari H, Kimura T, Arima Y, Sampetrean O, Nagaya M, Saito M, Saya H, Kosaki K, Nagashima H & Matsumoto M, Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts. Sci Rep. 2016 April 14;6:24413. DOI: 10.1038/srep24413
  • 後飯塚 僚Ryo Goitsuka
    1. Nakahara, R., Kawai, Y., Oda, A., Nishimura, M., Murakami, A., Azuma, T., Kaifu, T. and Goitsuka, R.: Generation of a Tlx1CreER-Venus knock-in mouse strain for the study of spleen development. Genesis, 52(11):916-923 (2014)
    2. Okumura, K., Saito, M., Aoto, Y., Hachiya, T., Sakakibara, Y., Katsuragi, Y., Hirose, S., Kominami, R., Goitsuka, R., Nakamura, T. and Wakabayashi, Y.: Meis1 regulates epidermal stem cells and is required for skin tumorigenesis. PLOS ONE, 9(7):e102111 (2014)
    3. Seki, Y., Kikuchi, Y., Yoshimoto, R., Aburai, K., Kanai, Y., Ruike, T., Iwabata, K., Goitsuka, R., Sugawara, F., Abe, M., and Sakaguchi, K.: Promotion of crystalline cellulose degradation by expansins from Orysa sativa. Planta, 241(1):83-93 (2015)
    4. Yokoyama, T., Nakatake, M., Kuwata, T., Goitsuka, R., Tsutsumi, S., Aburatani, H., Valk, P. J. M., Delwel, R. and Nakamura, T.: Tranactivation of Styl1/Slp1 by Meis1 promotes CXCL12/CXCR4 signaling and myeloid leukemogenesis in vivo. J. Clin. Invest., 2016, 126:1664-1678
  • 和田 直之Naoyuki Wada
    1. Yasumoto Y, Hashimoto C, Nakao R, Yamazaki H, Hiroyama H, Nemoto T, Yamamoto S, Sakurai M, Oike H, Wada N, Yoshida-Noro C, Oishi K. (2016) Short-term feeding at the wrong time is sufficient to desynchronize peripheral clocks and induce obesity with hyperphagia, physical inactivity and metabolic disorders in mice. Metabolism, 65 (5), 714-727. http://dx.doi.org/10.1016/j.metabol.2016.02.003
    2. Hrikawa, K., Hashimoto, C., Kikuchi, Y., Makita, M., Fukudome, S.-i., Okita, K., Wada N., Oishi, K. (2016). Wheat alkylresorcinols reduce micellar solubility of cholesterol in vitro and increase cholesterol excretion in mice. Natur. Product. Res. http://dx.doi.org/10.1080/14786419.2016.1198347.
  • 古市 貞一Teiichi Furuichi
    1. Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba,R., Sekine, Y., Sato, Y., Tanaka, M., Iwasato, T., Itohara, S., Furuyama, K., Kawaguchi, Y., Ishizaki, Y., Yuzaki, M., and Furuichi, T. CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain. J. Neurosci., 33:17326-17334, 2013
    2. Motoyoshi-Yamashiro, A., Tamura, M., Moriyama, M., Takano, K., Kawabe, K., Nakajima, H., Katoh-Semba, R., Furuichi, T., and Nakamura, Y. Activation of cultured astrocytes by amphotericin B: Stimulation of NO and cytokines production and changes in neurotrophic factors. Neurochem. Int. 63:93-100, 2013.
    3. Tanaka, M., Shih, PY., Gomi, H., Yoshida, H., Nakai, J., Ando, R., Furuichi, T., Mikoshiba, K., Semyanov, A., and Itohara, S. Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses. Mol. Brain 6:6, 2013
    4. Sadakata, T., Shinoda, Y., Oka, M., Sekine, Y., and Furuichi, T. Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene. FEBS Lett. 587:54-59, 2013
    5. Sadakata, T., Shinoda, Y., Sato, A., Iguchi, H., Ishii, C., Matsuo, M., Yamaga, R., and Furuichi, T. Mouse models of mutations and variations in autism spectrum disorder-associated genes: mice expressing Caps2/Cadps2 copy number and alternative splicing variants. Int. J. Environ. Res. Public Health, in press.
    6. Shinoda, Y., Sadakata, T., and Furuichi, T. Animal Models of Autism Spectrum Disorder (ASD): A Synaptic-level Approach to Autistic-like Behavior in Mice. Exp. Anim. 62(2), 71-78, 2013
    7. Okamura-Oho, Y., Shimokawa, K., Nishimura, M., Takemoto, S., Sato, A., Furuichi, T., and Yokota, H. Broad integration of expression maps and co-expression networks compassing novel gene functions in the brain. Sci. Rep. 4:6969, 2014
    8. Sato, Y., Yoshikawa, F., Sadakata, T., Shinoda, Y., Koebis, M., and Furuichi, T. Age-dependent redistribution and hypersialylation of the central myelin paranodal loop membrane protein Opalin in the mouse brain. Neurosci. Lett. 581: 14-19, 2014.
    9. Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba, R., Sekine, Y., Sato, Y., Saruta, C., Ishizaki, Y., Yuzaki, M., Kojima, M., and Furuichi, T. Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum. PLoS ONE 9(6): e99524, 2014
    10. Tanabe, K., Yamazaki, H., Inaguma, Y., Asada, A., Kimura, T., Takahashi, J., Taoka, M., Ohshima T., Furuichi, T., Isobe, T., Nagata, K., Shirao, T., and Hisanaga, S. Phosphorylation of Drebrin by Cyclin-Dependent Kinase 5 and Its Role in Neuronal Migration. PLoS ONE 9(3): e92291, 2014.
    11. Yoshikawa, F., Sato, Y., Tohyama, K., Akagi, T., Furuse, T., Sadakata, T., Tanaka, M., Shinoda, Y., Hashikawa, T., Itohara, S., Sano, Y., Ghandour, SM., Wakana, S., and Furuichi, T. Mammalian-specific central myelin protein Opalin is redundant for normal myelination: structural and behavioral assessments. PLoS ONE 11(11): e0166732, 2016
    12. Shinoda, Y., Ishii, C., Fukazawa, Y., Sadakata, T., Ishii, Y., Sano, Y., Iwasato, T., Itohara, S., and Furuichi, T. CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3–CA1 synapses in adult hippocampus. Scientific Rep. 6:31540, 2016
    13. Shinoda, Y., Nakajima, Y., Iguchi, H., Tatsumi, S., Kitaoka, M., Nakajima, M., Takahashi, T., Fujiwara, M., and Furuichi, T. Galacto-N-biose is neuroprotective against glutamate-induced excitotoxicity in vitro. Eur. J. Pharmacol. 791: 711-717, 2016
    14. Nakajima, Y., Iguchi, H., Kamisuki, S., Sugawara, F., Furuichi, T., and Shinoda, Y. Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. J. Toxicol. Sci., 41:311-319, 2016
    15. Hosono, M., Shinoda, Y., Hirano, T., Ishizaki, Y., Furuichi, T., and Sadakata, T. Interaction of Ca2+-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain. Neurosci. Lett. 617: 232–235, 2016
  • 中村 岳史Takeshi Nakamura
    1. Nakamura T, Yasuda S, Nagai H, Koinuma S, Morishita S, Goto A, Kinashi T, Wada N. Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase. Genes Cells. 2013 Nov;18(11):1020-31.
    2. Fujita A, Koinuma S, Yasuda S, Nagai H, Kamiguchi H, Wada N, Nakamura T. GTP Hhdrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70. PLoS One. 2013 8, e79689.
    3. Vance P Lemmon, Adam R Ferguson, Phillip G Popovich, Xiao-Ming Xu, Diane M Snow, Michio Igarashi, Christine E Beatle, and John L Bixby. 2014. Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments. J. Neurotrauma 31, 1354-1361.
    4. Toshinori Morisaku, Yuhei Wada, Takeshi Nakamura, and Hiroharu Yui. 2017. Role of actin filaments and microtubules on the viscoelastic properties of the pklasma membrane in a fibroblast cell studied with the laser-induced surface deformation microscope. Analyst. in press.
  • 樋上 賀一Yoshikazu Higami
    1. Matsuo T, Miyata Y, Sagara Y, Higami Y, Tobu S, Matsuo M, Noguchi M, Shimokawa I, Kanetake H, Sakai H. Renoprotective effects of telmisartan after unilateral renal ablation in rats. Int J Nephrol Renovasc Dis. 2013 Oct 10;6:207-14.
    2. Okita N, Yoshimura M, Watanabe K, Minato S, Kudo Y, Higami Y, Tanuma S. CHK1 cleavage in programmed cell death is intricately regulated by both caspase and non-caspase family proteases. Biochim Biophys Acta. 2013 Jan;1830(1):2204-13.
    3. Chujo Y, Fujii N, Okita N, Konishi T, Narita T, Yamada A, Haruyama Y, Tashiro K, Chiba T, Shimokawa I, Higami Y. Caloric restriction-associated remodeling of rat white adipose tissue: effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration. Age (Dordr). 2013 Aug;35(4):1143-56
    4. Miyano K, Sudo Y, Yokoyama A, Hisaoka-Nakashima K, Morioka N, Takebayashi M, Nakata Y, Higami Y, Uezono Y. History of the G Protein-Coupled Receptor (GPCR) Assays From Traditional to a State-of-the-Art Biosensor Assay. J Pharmacol Sci. 126(4):302-9, 2014
    5. Hatachi G, Tsuchiya T, Miyazaki T, Matsumoto K, Yamasaki N, Okita N, Nanashima A, Higami Y, Nagayasu T. The poly(adenosine diphosphate-ribose) polymerase inhibitor PJ34 reduces pulmonary ischemia-reperfusion injury in rats. Transplantation. 98(6):618-24, 2014
    6. Okita N, Ishikawa N, Mizunoe Y, Oku M, Nagai W, Suzuki Y, Matsushima S, Mikami K, Okado H, Sasaki T, Higami Y. Inhibitory effect of p53 on mitochondrial content and function during adipogenesis. Biochem Biophys Res Commun. 446(1):91-7, 2014
    7. Terawaki K, Sawada Y, Kashiwase Y, Hashimoto H, Yoshimura M, Suzuki M, Miyano K, Sudo Y, Shiraishi S, Higami Y, Yanagihara K, Kase Y, Ueta Y, Uezono Y. New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line. Am J Physiol Endocrinol Metab. 306(4):E373-87, 2014
    8. Okita N, Tsuchiya T, Fukushima M, Itakura K, Yuguchi K, Narita T, Hashizume Y, Sudo Y, Chiba T, Shimokawa I, Higami Y. Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats. Exp Gerontol. 63:59-66, 2015
  • 水田 龍信Ryusin Mizuta
    1. Arai, T., Koyama, R., Yuasa, M., Kitamura, D., Mizuta, R. Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose. BIOMEDICAL RESEARCH-TOKYO 35 (6): 389-395, (2014).
    2. Koyama, R., Arai, T., Kijima, M., Yuasa, M., Kitamura, D., Mizuta, R. Differential usage of DNase γ and DNase 1 to induce DNA degradation of dead cells in vivo. in preparation
    3. Koyama, R., Arai, T., Kijima, M., Sato, S., Miura, S., Yuasa, M., Kitamura, D., and Mizuta, R. DNase  DNase I and caspase-activated DNase cooperate to degrade dead cells. Genes to Cells 21, 1150–1163 (2016).
    4. Koyama, R. and Mizuta, R. Acrolein scavengers, cysteamine and N-benzylhydroxylamine, reduces the mouse liver damage after acetaminophen overdose. J. Vet. Med. Sci. 78, 1903–1905 (2016).
  • 大谷 直子Naoko Ohtani
    1. Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge R-M, Jan Vijg J, Van Steeg H, Dollé MET, Hoeijmakers JHJ, de Bruin A, Hara E, Campisi J. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell, 31, 722-33 (2014).
    2. Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, Nakanishi M. Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction. Molecular Cell, 55, 1–12 (2014).
    3. Imai Y, Takahashi A, Hanyuu A, Hori S, Sato S, Naka K, Hirao A, Ohtani N, Hara E. Crosstalk between the RB-pathway and AKT signaling forms a Quiescence-Senescence switch. Cell Reports, 7, 194-207 (2014).
    4. Tze Mun Loo, Fumitaka Kamachi, Yoshihiro Watanabe, Shin Yoshimoto Hiroaki Kanda, Yuriko Arai, Yaeko Nakajima-Takagi, Atsushi Iwama, Tomoaki Koga, Yukihiko Sugimoto, Takayuki Ozawa, Masaru Nakamura, Miho Kumagai, Koichi Watashi, Makoto M Taketo, Tomohiro Aoki10, Shuh Narumiya, Masanobu Oshima, Makoto Arita, Eiji Hara and Naoko Ohtani. Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity. Cancer Discovery, in press, 2017.
  • Yoichiro Iwakura
    1. Silverpil, E., Wright, A. K., Hansson, M., Jirholt, P., Henningsson, L., Smith, M. E., Gordon, S. B., Iwakura, Y., Gjertsson, I., Glader, P., and Linden, A. Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation. Innate Immun., 19, 479-492 (2013).
    2. Nakatsuka, A., Wada, J., Iseda, I., Teshigawara, S., Higashio, K., Murakami, K., Kanzaki, M., Inoue, K., Terami, T., Katayama, A., Hida, K., Eguchi, J., Ogawa, D., Matsuki, Y., Hiramatsu, R., Yagita, H., Kakuta, S., Iwakura, Y., and Makino, H. Vaspin inhibits apoptosis of endothelial cells as a ligand for cell-surface GRP78/VDAC complex. Circ. Res., 112, 771-780 (2013).
    3. Kurimoto, E., Miyahara, N., Kanehiro, A., Waseda, K., Taniguchi, A., Ikeda, G., Koga, H., Nishimori, H., Tanimoto, Y., Kataoka, M., Iwakura, Y., Gelfand, E. W., and Tanimoto, M. IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice. Respir. Res., 14, 5 (2013).
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    69. Seno, A., Maruhashi, T., Kaifu, T., Yabe, R., Fujikado, N., Ma, G., Ikarashi, T., Kakuta, S., and Iwakura, Y. Exacerbation of experimental autoimmune encephalomyelitis in mice deficient for DCIR, an inhibitory C-type lectin receptor. Exp. Anim., 2014 Dec 15. [Epub ahead of print]
    70. Mizushina, Y., Shirasuna, K., Usui, F., Karasawa, T., Kawashima, A., Kimura, H., Kobayashi, M., Komada, T., Inoue, Y., Mato, N., Yamasawa, H., Latz, E., Iwakura, Y., Kasahara, T., Bando, M., Sugiyama, Y., and Takahashi, M. NLRP3 deficiency exacerbates hyperoxia-induced lethality through Stat3 signaling independently of interleukin-1b. J. Biol. Chem., 2014 Dec 29. pii: jbc.M114.603217. [Epub ahead of print]
    71. Jee, J., Bonnegarde-Bernard, A., Duverger, A., Iwakura, Y., Cormet-Boyaka, E., Martin, T. L., Steiner, H. E., Bachman, R. C., and Boyaka, P. N. Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization. Mucosal Immunol., 2015 Jan 7. doi: 10.1038/mi.2014.105. [Epub ahead of print]
    72. Oyoshi, M. K., Beaupré, J., Venturelli, N., Lewis, C. N., Iwakura, Y., Geha, R. S. Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus. J. Allergy Clin. Immunol., 2015 Jan 30. pii: S0091-6749(15)00003-2. doi: 10.1016/j.jaci.2014.12.1923. [Epub ahead of print]
    73. Shimizu, K., Nakajima, A., Sudo, K., Liu, Y., Mizoroki, A., Ikarashi, T., Horai, R., Kakuta, S., Watanabe, T., and Iwakura, Y. Interleukin-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting interleukin-1 signal on macrophages. J. Immunol., in press.
    74. Uryu, H., Hashimoto, D., Kato, K, Hayase, E., Matsuoka, S., Ogasawara, R., Takahashi, S., Maeda, Y., Iwasaki, H., Miyamoto, T., Saijo, S., Iwakura, Y., Hill, G. R., Akashi, K., and Teshima, T. a-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. Blood. 2015 Mar 4. pii: blood-2014-12-615781. [Epub ahead of print]
    75. Mai J, Nanayakkara G, Lopez-Pastrana J, Li X, Li YF, Wang X, Song A, Virtue A, Shao Y, Shan H, Liu F, Autieri MV, Kunapuli SP, Iwakura Y, Jiang X, Wang H, Yang XF. Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK) Pathway. J Biol Chem. (2016); 291:4939-54.
    76. Kawabe T, Suzuki N, Yamaki S, Sun SL, Asao A, Okuyama Y, So T, Iwakura Y, Ishii N. Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice. Eur J Immunol. (2016); 46:1119-31.
    77. Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Cappelletti M, Huppert SS, Iwakura Y, Dong C, Shanmukhappa SK, Divanovic S. Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. PLoS One. (2016); 11:e0149783.
    78. Lee EJ, Brown BR, Vance EE, Snow PE, Silver PB, Heinrichs D, Lin X, Iwakura Y, Wells CA, Caspi RR, Rosenzweig HL. Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye. J Immunol. (2016); 196:3148-58.
    79. Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y, Takayanagi H. IL-17-producing γδ T cells enhance bone regeneration. Nat Commun. (2016); 7:10928.
    80. Ciraci C, Janczy JR, Jain N, Haasken S, Pecli E Silva C, Benjamim CF, Sadler JJ, Olivier AK, Iwakura Y, Shayakhmetov DM, Sutterwala FS, Cassel SL. Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo. PLoS One. (2016); 11:e0151252.
    81. Javed N, Xue G, Lu A, Xing Y, Iwakura Y, Xiao H, Lecoeur H, Späth GF, Meng G. Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy. Cytokine. (2016); 81:101-8.
    82. Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X. T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Nat Immunol. (2016); 17:583-92.
    83. Shishikura M, Nakamura F, Yamashita N, Uetani N, Iwakura Y, Goshima Y. Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system. Brain Res. (2016); 1642:244-54.
    84. Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS. Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. Hypertension. (2016); 68:167-74.
    85. Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S. Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis. Innate Immun. (2016); 22:316-24.
    86. Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA. Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity. J Immunol. (2016); 197:278-87.
    87. Masamoto Y, Arai S, Sato T, Yoshimi A, Kubota N, Takamoto I, Iwakura Y, Yoshimura A, Kadowaki T, Kurokawa M. Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation. Immunity. (2016); 44:1422-33.
    88. Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N. Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells. J Biol Chem. (2016); 291:17629-38.
    89. Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y. IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression. Cancer Sci. (2016); 107:1206-14.
    90. Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K. The potential for repositioning antithyroid agents as antiasthma drugs. J Allergy Clin Immunol. (2016); 138:1458-1461.
    91. Niu X, Liu W, Wang Y, Liu X, Zhang H, Li Z, Li H, Iwakura Y, Deng W. IL-17A exacerbates cisplatin-based resistance of OVCA via upregulating the expression of ABCG2 and MDR1 through Gli1-mediated Hh signaling. Oncotarget. (2016); doi: 10.18632/oncotarget.10655.
    92. Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY. Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713-2722; DOI: 10.2337/db05-1430. Diabetes. (2016); 65:2462.
    93. Huang Y, Matsumura Y, Hatano S, Noguchi N, Murakami T, Iwakura Y, Sun X, Ohara N, Yoshikai Y. IL-21 inhibits IL-17A-producing γδ T-cell response after infection with Bacillus Calmette-Guérin via induction of apoptosis. Innate Immun. (2016); 22:588-597.
    94. Murakami T, Hatano S, Yamada H, Iwakura Y, Yoshikai Y. Two Types of Interleukin 17A-Producing γδ T Cells in Protection Against Pulmonary Infection With Klebsiella pneumoniae. J Infect Dis. (2016); 214:1752-1761.
    95. Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M. Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells. Stem Cells. (2016); doi: 10.1002/stem.2524.
    96. Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H. Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells. J Immunol. (2017); 198:61-70.
    97. Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T. The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis. Proc Natl Acad Sci U S A. (2016); 113:14097-14102.
    98. Umemura M, Okamoto-Yoshida Y, Yahagi A, Touyama S, Nakae S, Iwakura Y, Matsuzaki G. Involvement of IL-17A-producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection. Immun Inflamm Dis. (2016); 4:401-412.
    99. Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ. Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation. Immunity. (2016); 45:1299-1310.
    100. Inoue SI, Niikura M, Asahi H, Iwakura Y, Kawakami Y, Kobayashi F. Preferentially expanding Vγ1+ γδ T cells are associated with protective immunity against Plasmodium infection in mice. Eur J Immunol. (2016); doi: 10.1002/eji.201646699.
    101. Kaifu, T., and Iwakura, Y. Dendritic cell immunoreceptor (DCIR): An ITIM-harboring C-type lectin receptor. In “C-Type Lectin Receptor in Immunity”, (ed. Sho Yamasaki) (ISBN: 978-4-431-56013-5, DOI: 10.1007/978-4-431-56015-9_7), Springer Japan, p. 101-113 (2016).
    102. Takagi N, Kawakami K, Kanno E, Tanno H, Takeda A, Ishii K, Imai Y, Iwakura Y, Tachi M. IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin. Exp Dermatol. (2017); 26:137-144.
    103. Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y, Inaba K, Takahara K. Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice. Eur J Immunol. (2017); doi: 10.1002/eji.201646814.
    104. Akitsu A, Iwakura Y. Isolation of joint-infiltrating cells. Bio-Protocol. (in press, DOI: https://doi.org/10.21769/BioPtotoc.1911) (2017)
    105. Furukawa, K., Fuse, I., Iwakura, Y., Sotoyama, H., Hanyu, O., Nawa, H., Sone, H., and Takei, N. Advanced glycation end products induce brain-derived neurotrophic factor release from human plateltets through the Src-family kinase activation. Cardiovasc. Diabetol., (2017); 16, 20. doi: 10.1186/s12933-017-0505-y.
    106. Yan, X., Zhang, H., Fan, Q., Hu, J., Tao, R., Chen, Q., Iwakura, Y., Shen, W., Lu, L., Zhang, Q., and Zhang, R. Dectin-2 deficiency modulates Th1 differentiation and improves wound healing after myocardial infarction. Circ. Res., (2017 Feb 13). pii: CIRCRESAHA.116.310260. doi:10.1161/CIRCRESAHA.116.310260. [Epub ahead of print]
  • Masato Kubo
    1. Firth, M.A., Madera,S., Aimee M. Beaulieu, A.M., Gasteiger,G., Schluns, K.S., Kubo, M, Rothman, P.B., Vivier, E., and Sun, J.C.;Nfil3-independent lineage maintenance of natural killer cells. J.Exp.Med. in press
    2. Noti, M., Tait, E.D., Wojno, T., Kim, B. S. Siracusa, M.C., Giacomin, P.R., Nair, M.G., Kubo, M., Alain J. Benitez, A.J., Ruymann, K.R., Comeau, M.R., Cianferoni, A., Wang, M., Spergel, J.S., and Artis, D., Heterogeneous immunologic pathways underlie the pathogenesis of the allergic march. Nature Medicine 2013,19(8):1005-13,
    3. Matsunaga, A., Fukuyama, S., Okuno, T., Sasaki, F., Matsunobu, T., Asai, Y., Matsumoto, K., Saeki, K., Oike, M., Sadamura, Y., Machida, K., Nakanishi, Y., Kubo, M., Yokomizo, T., Inoue, H., Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia, The FASEB Journal 2013, 27(8):3306-14
    4. Kubo, M., Therapeutic hope for psoriasis offered by SOCS mimetic peptide. Eur. J. Immunol. 2013, 43(7):1702-5
    5. Furusawa, J., Moro, K., Motomura, Y., Okamoto, K., Zhu, J., Takayanagi, H., Kubo, M., Koyasu, S., Critical role of p38 and GATA3 in natural helper cell function. J. Immunol. 2013, 191(4):1818-26
    6. Otsuka, A., Nakajima S, Kubo M, Egawa G, Honda T, Kitoh A, Nomura T, Hanakawa S, Sagita Moniaga C, Kim B, Matsuoka S, Watanabe T, Miyachi Y, Kabashima, K., : Basophils are required for the induction of Th2 immunity to haptens and peptide antigens. Nature Communication 2013, 4:1738.
    7. Nakajima, S., Kitoh, A., Egawa, G., Natsuaki, Y., Nakamizo, S., Moniaga, C.A., Otsuka, A., Honda, T., Hanakawa, S., Amano, W., Iwakura, Y., Nakae, S., Kubo, M., Miyachi,Y., and Kabashima, K.: IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models Journal of Investigative Dermatology 134(8):2122-30 2014
    8. Kurashima, Y., Amiya, T., Fujisawa, K., Shibata, N., Suzuki, Y., Kogure, Y., Hashimoto, E., Otsuka, A., Kabashima, K., Sato, S., Kubo, M., Yokota, Y., Akira, S., Miyake, K., Kunisawa, J., and Kiyono, H. The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrierhomeostasis. Immunity 40 (4): 530-541, 2014
    9. Nakashima, C., Otsuka, A., Kitoh, A., Honda,T., Egawa,G., Nakajima,S., Nakamizo,S., Arita, M., Kubo, M., Miyachi,Y., and Kabashima, K.: Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis. Journal of Allergy and Clinical Immunology134(1):100-7..2014.
    10. Motomura, Y., Morita, H., Moro, K., Nakae, S., Artis, D., Koyasu,S., Kubo, M. Basophil-derived IL-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. Immunity 40 (5): 758–771, 2014
    11. Noti, M., Kim, B.S., Siracusa, M.C., Rak, G.D., Kubo, M., Moghaddam, A.E., Sattentau, Q.A., Comeau, M.R., Spergel, J.M., and Artis, D.,; Exposure to food allergens through inflamed 1 skin promotes intestinal food allergy via the TSLP-basophil axis. Journal of Allergy and Clinical Immunology 133(5):1390-9, 2014
    12. Moriyama, S., Takahashi, N., Green, J.A., Kubo, M., Cyster J.G. and Okada, T., Sphingosine-1-phosphate receptor 2 controls follicular helper T cell localization to support germinal center response. J.Exp.Med. 211(7), 1297-1305, 2014
    13. Wataru Ise, Takeshi Inoue, James B McLachlan, Kohei Kometani, Kubo, M., Takaharu Okada and Tomohiro Kurosaki : Memory B cells contribute to rapid Bcl6 expression of memory TFH cells. Proc. Natl. Acad. Sci. U.S.A. 111(32):11792-7 2014
    14. Brian S. Kim, Mark C. Siracusa, Kelvin Wang, Steven A. Saenz, Kubo, M., and David Artis: Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin. J. Immunol. 193(7):3717-25, 2014
    15. Natsuaki, Y., Egawa, G., Nakamizo, S., Hanakawa, S., Ono, S., Okada, T., Kusuba, N., Otsuka, A., Kitoh, A., Honda, T., Nakajima, S., Tsuchiya, S., Sugimoto, Y., Ishii, J. K., Tsutsui, H., Yagita, H., Iwakura, Y., Kubo, M., Hashimoto, T., Fuentes, J., Guttman-Yassky, E., Miyachi, Y., and Kabashima, K., : Perivascular leukocyte cluster: an essential structure for efficient effector T cell activation in the skin. Nature Immunology 15(11):1064-9, 2014
    16. Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl4, Véronique Braud, Barbara Kee, Hugh Brady, Mark C.Coles, Christian Vosshenrich, Kubo, M., James P. Di Santo and Henrique Veiga-Fernandes:NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors. Cell Report in press
    17. Nakano, N., Nishiyama, C., Yagita, H., Hara, M., Motomura, Y., Kubo, M., Okumura, K., and Ogawa, H., Notch signaling enhances FceRI-mediated cytokine production by mast cells through direct and indirect mechanisms. J. Immunol. in press
    18. Ugajin, T., Nishida, K., Yamasaki, S., Suzuki, J., Mita, M., Kubo, M., Yokozeki, H., Hirano, T., : Zinc-binding metallothioneins are key modulators of IL-4 production by basophils Molecular Immunology in press
    19. Takeuchi, A., Badr, M.E.S., Miyauchi, K., Ishihara, C. Onishi, R., Guo, Z., Sasaki, Y., Ike, H., Takumi, A., Tsuji, N., Murakami, Y., Katakai,T., Kubo, M., and Saito, T., CRTAM determines the CD4+ cytotoxic T lymphocyte lineage, J. Exp. Med. 213:123-138, 2016
    20. Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo, M., Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H.: Jak1 tyrosine kinase hyperactivation induces spontaneous progressive pruritic dermatitis. J. Clin. Invest. 126(6):2064–2076. 2016
    21. Miyauchi, K., Sugimoto-Ishige, A., Harada, Y., Adachi, Y., Usami, Y., Kaji, T., Hasegawa, H., Watanabe, T., Hijikata, A., Fukuyama, S., Maemura, T., Ohara, O., Kawaoka, Y., Takahashi, Y., Takemori, T., and Kubo, M.,: Protective neutralizing influenza antibody response in the absence of T follicular helper cells. Nature Immunology 17(12), p1447-1458, 2016
    22. Elisa Domínguez-Hüttinger, Panayiotis Christodoulides, Kosuke Miyauchi, Alan D Irvine, Mariko Okada-Hatakeyama, Kubo, M., and Reiko J Tanaka, Mathematical Modeling of Atopic Dermatitis Reveals “Double switch” Mechanisms Underlying Four Common Disease Phenotypes, Journal of Allergy and Clinical Immunology pii:S0091-6749 (16) 31433-6, 2016
    23. Satoshi Tsurusaki, Satoko Tahara-Hanaoka, Shota Miyake, Shohei Shibagaki, Masamichi Imai, Shiro Shibayama, Kubo, M., Akira Shibuya: Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis. Int.Immunol. 28(12):605-609, 2016
    24. Shirota, H., Klinman, D.M., Ito, SE., Ito, H., Kubo, M.,, Ishioka, C.,: IL4 from T follicular helper cells downregulates antitumor immunity. Cancer Immunology Research, 5(1):61-71, 2017
    25. Maryam Hussain, Loïc Borcard, Kevin P. Walsh, Maria Pena Rodriguez, Kubo, M., Christoph Mueller, Brian S. Kim, David Artis, Mario Noti,; Basophil-derived interleukin-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy. Journal of Allergy and Clinical Immunology, in press, 2017
    26. Kubo, M., T follicular helper and Th2 cells in allergic responses. Allergology International invited review 2017
    27. Kubo, M., Innate and adaptive type 2 immunity in lung allergic inflammation. Immunological Review invited review 2017
  • Daisuke Kitamura
    1. Moutai, T., Yamana, H., Nojima, T. and Kitamura, D. A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. PLoS One 9: e92732, 2014.
    2. Fukao, S., Haniuda, K., Nojima, T., Takai, T. and Kitamura, D. Gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells. J. Immunol. 193: 635-644, 2014.
    3. Wu, L., Parekh, V.V., Hsiao, J., Kitamura, D. and Van Kaer, L. Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance. Proc. Natl. Acad. Sci. USA 111: E4638-E4647, 2014.
    4. Kitabatake, M., Soma, M., Zhang, T., Kuwahara, K., Fukushima, Y., Nojima, T., Kitamura, D. and Sakaguchi, N. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. J. Immunol. 194:1480-1488, 2015.
    5. Webb, L.M., Datta, P., Bell, S.E., Kitamura, D., Turner, M. and Butcher, G.W. GIMAP1 is essential for the survival of naive and activated B cells in vivo. J. Immunol. 196: 207-216, 2016.
    6. Kuraoka, M., Schmidt, A.G., Nojima, T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S.C., Kepler, T.B. and Kelsoe, G. Complex antigens drive permissive clonal selection in germinal centers. Immunity 44: 542-552, 2016.
    7. Domeier, P.P., Chodisetti, S.B., Soni, C., Schell, S.L., Elias, M.J., Wong, E.B., Cooper, T.K., Kitamura, D. and Rahman, Z.S. IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J. Exp. Med. 213: 715-732, 2016.
    8. Haniuda, K., Fukao, S., Kodama, T., Hasegawa, H. and Kitamura, D. Autonomous membrane IgE signaling prevents IgE-memory formation. Nat. Immunol. 17: 1109-1117, 2016.
    9. Koyama, R., Arai, T., Kijima, M., Sato, S., Miura, S., Yuasa, M., Kitamura, D., Mizuta, R. DNase γ, DNase I and caspase-activated DNase cooperate to degrade dead cells. Genes Cells 21:1150-1163, 2016.
    10. Lee, P., Zhu, Z., Hachmann, J., Nojima, T., Kitamura, D., Salvesen, G. and Rickert, R.C. Differing requirements for MALT1 function in peripheral B cell survival and differentiation. J. Immunol. 198:1066-1080, 2017.
  • Naoko Nakano
    1. Shibuya K., and Nakano N. Interleukin-2 drives immature double negative thymocytes into gd T cells expressing Foxp3 on a stromal cell line in vitro. Biochem. Biophys. Res. Commn. 452: 912-919, 2014
  • Haruo Kozono
    1. Haruo Kozono, Yufuku Matsushita, Naoki Ogawa, Yuko Kozono, Toshihiro Miyabe, Hiroshi Sekiguchi, Kouhei Ichiyanagi, Noriaki Okimoto, Makoto Taiji, Osami Kanagawa, Yuji C. Sasaki: Single Molecular Motions of MHC Class II Rely on Bound Peptides. Biophysical journal 108: 350-9. (2015)
    2. Yuko Kozono, Ryuma Tanizawa, Sae Sato, Naoki Ogawa, Hiroshi Sekiguchi, Satoshi Ishido, Yuji C. Sasaki, Osami Kanagawa, Haruo Kozono: Peptides dependent ubiquitination of major histocompatibility complex class II protein. in prep.
  • Syuhei Ogawa
    1. Shimizu R., Umezawa M., Okamoto S., Onoda A., Uchiyama M., Tachibana K., Watanabe S., Ogawa S., Abe R., Takeda K. Effect of maternal exposure to carbon black nanoparticle during early gestation on the splenic phenotype of neonatal mouse. J. Toxicol. Sci. 39, 571-578 (2014).
    2. Aoki, S., Tanaka, T., Tsukimoto, M., Mori, N., Nishino, K., Tanamachi, K., Abe, R., Suzuki, T., Ogawa, S., Wakamatsu, E., Horie, K., Sakurai, Y., Tanaka, H., and Ono, K.: Establishment of Innovative Combination Therapy with Boron Neutron Capture Therapy and Immune Therapy, Kyoto Univ. Research Reactor (KUR) Pregress Report (2014).
    3. Akieda, Y., Wakamatsu, E., Nakamura, T., Ishida, Y., Ogawa, S., and Abe, R.: Defects in regulatory T cells due to CD28-deficiency induce a qualitative change of allogeneic immune response in chronic graft-versus-host disease. J. Immunol., in press (2015).
    4. Ohtsuka, S., Ogawa, S., Wakamatsu, E., and Abe, R. Cell cycle arrest caused by MEK/ERK signaling is a mechanism for suppressing growth of antigen-hyperstimulated effector T cells. Int. Immunol. 28(11):547-557 (2016)
    5. Inaba, S., Numoto, N., Ogawa, S., Morii, H., Ikura, T., Abe, R., Ito, N. and Oda, M. Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the SH2 Domains of Three Adaptor Proteins. J. Biol. Chem. 292(3):1052-1060 (2017)
  • Mitsutoshi Tsukimoto
    1. Toki Y, Takenouchi T, Harada H, Tanuma SI, Kitani H, Kojima S, Tsukimoto M. Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death. Biochem Biophys Res Commun. (2015) in press
    2. Kawano A, Hayakawa A, Kojima S, Tsukimoto M, Sakamoto H, Purinergic signaling mediates oxidative stress in UVA-exposed THP-1 cells. Toxicology reports (2015) in press
    3. Kawakami Y, Murashima YL, Tsukimoto M, Baba A, Miyatake C, Okazaki T, Takagi A, Koizumi S, Kojima S, Fujino O, Itoh Y. Significance of glutathione-mediated scavenger potency in the development of seizure susceptibility in the EL mouse brain. Journal of Pediatric Epilepsy (2015) in press
    4. Takai E, Tsukimoto M, Harada H, Kojima S. Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells. Purinergic Signal. 2014 Sep;10(3):487-97.
    5. Takenouchi T, Suzuki S, Shinkai H, Tsukimoto M, Sato M, Uenishi H, Kitani H. Extracellular ATP does not induce P2X7 receptor-dependent responses in cultured renal- and liver-derived swine macrophages. Results Immunol. (2014) 4:62-7.
    6. Ishimaru M, Yusuke N, Tsukimoto M, Harada H, Takenouchi T, Kitani H, Kojima S. Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells. J Toxicol Sci. (2014) 39(3):413-23.
    7. Nagakura C, Negishi Y, Tsukimoto M, Itou S, Kondo T, Takeda K, Kojima S. Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes. Toxicology. (2014) 1;322:61-8.
    8. Kojima S, Negishi Y, Tsukimoto M, Takenouchi T, Kitani H, Takeda K. Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle. Toxicology. (2014) 3;321:13-20.
    9. Kaji W, Tanaka S, Tsukimoto M, Kojima S. Adenosine A(2B) receptor antagonist PSB603 suppresses tumor growth and metastasis by inhibiting induction of regulatory T cells. J Toxicol Sci. (2014) 39(2):191-8.
    10. Ide S, Nishimaki N, Tsukimoto M, Kojima S. Purine receptor P2Y6 mediates cellular response to γ-ray-induced DNA damage. J Toxicol Sci. (2014) 39(1):15-23.
    11. Nishino K, Tanamachi K, Nakanishi Y, Ide S, Kojima S, Tanuma S, Tsukimoto M., Radiosensitizing Effect of TRPV1 Channel Inhibitors in Cancer Cells. Biol Pharm Bull. (2016) 39(7):1224-30.
    12. Nakanishi K, Tsukimoto M, Tanuma S, Takeda K, Kojima S., Silica nanoparticles activate purinergic signaling via P2X7 receptor in dendritic cells, leading to production of pro-inflammatory cytokines. Toxicol In Vitro. (2016) 35:202-11.
    13. Ninomiya Y, Tanuma SI, Tsukimoto M., Differences in the effects of four TRPV1 channel antagonists on lipopolysaccharide-induced cytokine production and COX-2 expression in murine macrophages. Biochem Biophys Res Commun. (2017) (in press)
  • Fumio Fukai
    1. Tenascin-C-derived Peptide TNIIIA2 Highly Enhances Cell Survival and PDGF-dependent Cell Proliferation through Potentiated and Sustained Activation of Integrin a5b1.Tanaka R., Seki, Y., Kamiya S., Saito Y., Fujita, M., Okutsu, H., Iyoda T., Takai, T., Owaki T., Yajima H., Taira J., Hayashi R., Kodama, H., Matsunaga, T., and Fukai F. J Biol Chem. i289:17699−17708, 2014
    2. A novel mechanism underlying the basic defensive response of macrophages against Mycobacterium infection. Iyoda T., Takada, M., Fukatsu, K., Kumokoshi, S., Fujisawa, T., Shimada, T.,Shimokawa, N., Matsunaga, T., Makino, K., Doi, N., Terada, H., and Fukai, F. J. Immnunol. 192: 4254-4262, 2014
    3. Cell regulation through adhesion to the extracellular matrix via adhesion molecule, integrins —Therapeutic application of integrin activation-modulating peptides—Matsunaga T., Iyoda T. and Fukai F. in Colloid and Interface Science in Pharmaceutical Research and Development. Ed. Ohshima H., in press Elsevier 2013
    4. Takagi, R., Kobayashi , S., Yamato, M, Owaki, T., Kasai, Y., Takeda, N., Fukai, F., Eguchi, S., and Okano, T. How to prevent contamination with Candida albicans during the fabrication of transplantable pral mucosal epithelial cell sheets. Regenerative Therapy 29, 1-4, (2015)
    5. Iyoda, T., Kazama, M., Fuikai, F., Role of the Tenascin-C-Derived Peptide TNIIIA2 in the Formation of Atherosclerotic Foam Cell. Peptide Science 2014, 61-64, (2015).
    6. Maeda, M., Kanai, N., Kobayashi, S., Hosoi, T., Takagi, R., Yamato, M., Eguchi, S., Fukai, F., Okano, T., Endoscopic cell sheet transplantation device developed by using a 3-dimensional printer and its feasibility evaluation in a porcine model. GASTROINTESTINAL ENDOSCOPY, 82, 147 – 152 (2015)
    7. Kobayashi S, Kanai N, Tanaka N, Maeda M, Hosoi T, Fukai F, Eguchi S, Yamato M., Transplantation of epidermal cell sheets by endoscopic balloon dilatation to avoid esophageal re-strictures: initial experience in a porcine model., Endosc Int Open. 4(11):E1116-E1123.(2016)
    8. Kuga A., Imaizumi T., Iyoda T, & Fukai F., Membrane Expression of Eukaryotic Protein Elongation Factor (eEF) 1A and its Physiological Role, Peptide Science, 2015: 235 – 238 (2016)
    9. Onuma W, Tomono S, Miyamoto S, Fujii G, Hamoya T, Fujimoto K, Miyoshi N, Fukai F, Wakabayashi K, Mutoh M., Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice. Oncotarget. 7(8):8640-52 (2016)
    10. Iyoda T., & Fukai F., Promotion of Macrophage Foam Cell Formation by the Peptide Derived from Tenascin-C, Peptide Science, 2015: 203 – 206 (2016)
    11. Imaizumi T., Kuga A., Iyoda T., & Fukai F., Participation of Membrane-Type eEF1A in Migration, Invasion, and Metastasis of Tumor Cells, Peptide Science, 2015:193 – 196, (2016)
    12. Iyoda T, Nagamine Y, Nakane Y, Tokita Y, Akari S, Otsuka K, Fujita M, Itagaki K, Takizawa Y, Orita H, Owaki T, Taira J, Hayashi R, Kodama H, & Fukai F., Coadministration of the FNIII14 Peptide Synergistically Augments the Anti-Cancer Activity of Chemotherapeutic Drugs by Activating Pro-Apoptotic Bim, PLoS One 11(9), eO162525 (2016)
    13. Suzuki H, Sasada M, Kamiya S, Ito Y, Watanabe H, Okada Y, Ishibashi K, Iyoda T, Yanaka A, & Fukai F., The Promoting Effect of the Extracellular Matrix Peptide TNIIIA2 Derived from Tenascin-C in Colon Cancer Cell Infiltration., Int J Mol Sci. 18(1). pii: E181. (2017)
  • Takashi Tsuji
    1. Ogawa M, Oshima M, Imamura A, Sekine Y, Ishida K, Yamashita K, Nakajima K, Hirayama M, Tachikawa T, Tsuji T., Functional salivary gland regeneration by transplantation of a bioengineered organ germ. Nature Communications 4:2498. doi: 10.1038/ncomms3498, 2013.
    2. Hirayama M, Ogawa M, Oshima M, Sekine Y, Ishida K, Yamashita K, Ikeda K, Shimmura S, Kawakita T, Tsubota K, Tsuji T. Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ. Nature Communications 4:2498. doi: 10.1038/ncomms3497, 2013.
    3. Kentaro Ishida, Yohei Yuge, Mai Hanaoka, Masato Yasukawa, Yoko Minami, Miho Ogawa, Ko-hei Masumoto, Yasufumi Shigeyoshi, Masahiro Saito, Takashi Tsuji, Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression, Genes to Cells, 18(8), 660-671, 2013
    4. Masato Yasukawa, Kentaro Ishida, Yohei Yuge, Mai Hanaoka, Yoko Minami, Miho Ogawa, Takashi Sasaki, Masahiro Saito, Takashi Tsuji, Dpysl4 Is Involved in Tooth Germ Morphogenesis through Growth Regulation, Polarization and Differentiation of Dental Epithelial Cells. International Journal of Biological Sciences 9(4),382-390, 2013
    5. Jun Ishikawa, Masamitsu Oshima, Fumitaka Iwasaki, Ryoji Suzuki, Joonhong Park, Kazuhisa Nakao, Yuki Matsuzawa-Adachi, Taro Mizutsuki, Ayaka Kobayashi, Yuta Abe, Eiji Kobayashi, Katsunari Tezuka & Takashi Tsuji, Hypothermic temperature effects on organ survival and restoration, Scientific Reports, in Press.
    6. Sara Yajima-Himuro, Masamitsu Oshima, Gou Yamamoto, Miho Ogawa, Madoka Furuya, Junichi Tanaka, Kousuke Nishii, Kenji Mishima, Tetsuhiko Tachikawa, Takashi Tsuji & Matsuo Yamamoto, The junctional epithelium originates from the odontogenic epithelium of an erupted tooth. Scientific Reports 4:4867. DOI: 10.1038/srep0486, 2014
    7. Masamitsu Oshima, Kaoru Inoue, Kei Nakajima, Tetsuhiko Tachikawa, Hiromichi Yamazaki,Tomohide Isobe, Ayaka Sugawara, Miho Ogawa, Chie Tanaka, Masahiro Saito, Shohei Kasugai,Teruko Takano-Yamamoto, Takashi Inoue, Katsunari Tezuka, Takuo Kuboki, Akira Yamaguchi & Takashi Tsuji, Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy. Scientific Reports 4:6044. DOI: 10.1038/srep06044, 2014
    8. Miho Ogawa, Kentaro Yamashitac, Minori Niikurad, Kei Nakajima, Koh-ei Toyoshima, Masamitsu Oshima, Takashi Tsuji Saliva secretion in engrafted mouse bioengineered salivary glands using taste stimulation, Journal of Prosthodontic Research 58(1):17-25, Doi: 10.1016/j.jpor.2013.12.001, 2014.
    9. Ritsuko Morita, Miho Kihira, Yousuke Nakatsu, Yohei Nomoto, Miho Ogawa, Kazumasa Ohashi, Kensaku Mizuno, Tetsuhiko Tachikawa, Yukitaka Ishimoto, Yoshihiro Morishita, and Takashi Tsuji, Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations, PLoS One, 11(9):e0161336, 2016.
    10. Kei Nakajima, Masamitsu Oshima, Naomi Yamamoto, Chie Tanaka, Ryosuke Koitabashi, Takashi Inoue and Takashi Tsuji, Development of a Functional Biohybrid Implant Formed from Periodontal Tissue Utilizing Bioengineering Technology. Tissue Engineering Part A, 22(17-18): 1108-1015, 2016.
    11. Ryoji Takagi, Junko Ishimaru, Ayaka Sugawara, Koh-ei Toyoshima, Kentaro Ishida, Miho Ogawa, Kei Sakakibara, Kyosuke Asakawa, Akitoshi Kashiwakura, Masamitsu Oshima, Ryohei Minamide, Akio Sato, Toshihiro Yoshitake, Akira Takeda, Hiroshi Egusa and Takashi Tsuji, Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model, Science Advances, 2(4):e1500887, doi: 10.1126/sciadv.1500887, 2016.
  • Masahiro Saito
    1. Aino M, Nishida E, Fujieda Y, Orimoto A, Mitani A, Noguchi T, Makino H, Murakami S, Umezawa A, Yoneda T, Saito M. Isolation and characterization of the human immature osteoblast culture system from the alveolar bones of aged donors for bone regeneration therapy. Expert Opin Biol Ther. 2014 Dec;14(12):1731-44. doi: 10.1517/14712598.2014.960387. Epub 2014 Sep 22
    2. Oshima M, Inoue K, Nakajima K, Tachikawa T, Yamazaki H, Isobe T, Sugawara A, Ogawa M, Tanaka C, Saito M, Kasugai S, Takano-Yamamoto T, Inoue T, Tezuka K, Kuboki T, Yamaguchi A, Tsuji T. Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy. Sci Rep. 2014 Aug 13;4:6044. doi: 10.1038/srep06044.
    3. Umeyama K, Watanabe K, Watanabe M, Horiuchi K, Nakano K, Kitashiro M, Matsunari H, Kimura T, Arima Y, Sampetrean O, Nagaya M, Saito M, Saya H, Kosaki K, Nagashima H & Matsumoto M, Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts. Sci Rep. 2016 April 14;6:24413. DOI: 10.1038/srep24413
  • Ryo Goitsuka
    1. Nakahara, R., Kawai, Y., Oda, A., Nishimura, M., Murakami, A., Azuma, T., Kaifu, T. and Goitsuka, R.: Generation of a Tlx1CreER-Venus knock-in mouse strain for the study of spleen development. Genesis, 52(11):916-923 (2014)
    2. Okumura, K., Saito, M., Aoto, Y., Hachiya, T., Sakakibara, Y., Katsuragi, Y., Hirose, S., Kominami, R., Goitsuka, R., Nakamura, T. and Wakabayashi, Y.: Meis1 regulates epidermal stem cells and is required for skin tumorigenesis. PLOS ONE, 9(7):e102111 (2014)
    3. Seki, Y., Kikuchi, Y., Yoshimoto, R., Aburai, K., Kanai, Y., Ruike, T., Iwabata, K., Goitsuka, R., Sugawara, F., Abe, M., and Sakaguchi, K.: Promotion of crystalline cellulose degradation by expansins from Orysa sativa. Planta, 241(1):83-93 (2015)
    4. Yokoyama, T., Nakatake, M., Kuwata, T., Goitsuka, R., Tsutsumi, S., Aburatani, H., Valk, P. J. M., Delwel, R. and Nakamura, T.: Tranactivation of Styl1/Slp1 by Meis1 promotes CXCL12/CXCR4 signaling and myeloid leukemogenesis in vivo. J. Clin. Invest., 2016, 126:1664-1678
  • Naoyuki Wada
    1. Yasumoto Y, Hashimoto C, Nakao R, Yamazaki H, Hiroyama H, Nemoto T, Yamamoto S, Sakurai M, Oike H, Wada N, Yoshida-Noro C, Oishi K. (2016) Short-term feeding at the wrong time is sufficient to desynchronize peripheral clocks and induce obesity with hyperphagia, physical inactivity and metabolic disorders in mice. Metabolism, 65 (5), 714-727. http://dx.doi.org/10.1016/j.metabol.2016.02.003
    2. Hrikawa, K., Hashimoto, C., Kikuchi, Y., Makita, M., Fukudome, S.-i., Okita, K., Wada N., Oishi, K. (2016). Wheat alkylresorcinols reduce micellar solubility of cholesterol in vitro and increase cholesterol excretion in mice. Natur. Product. Res. http://dx.doi.org/10.1080/14786419.2016.1198347.
  • Teiichi Furuichi
    1. Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba,R., Sekine, Y., Sato, Y., Tanaka, M., Iwasato, T., Itohara, S., Furuyama, K., Kawaguchi, Y., Ishizaki, Y., Yuzaki, M., and Furuichi, T. CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain. J. Neurosci., 33:17326-17334, 2013
    2. Motoyoshi-Yamashiro, A., Tamura, M., Moriyama, M., Takano, K., Kawabe, K., Nakajima, H., Katoh-Semba, R., Furuichi, T., and Nakamura, Y. Activation of cultured astrocytes by amphotericin B: Stimulation of NO and cytokines production and changes in neurotrophic factors. Neurochem. Int. 63:93-100, 2013.
    3. Tanaka, M., Shih, PY., Gomi, H., Yoshida, H., Nakai, J., Ando, R., Furuichi, T., Mikoshiba, K., Semyanov, A., and Itohara, S. Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses. Mol. Brain 6:6, 2013
    4. Sadakata, T., Shinoda, Y., Oka, M., Sekine, Y., and Furuichi, T. Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene. FEBS Lett. 587:54-59, 2013
    5. Sadakata, T., Shinoda, Y., Sato, A., Iguchi, H., Ishii, C., Matsuo, M., Yamaga, R., and Furuichi, T. Mouse models of mutations and variations in autism spectrum disorder-associated genes: mice expressing Caps2/Cadps2 copy number and alternative splicing variants. Int. J. Environ. Res. Public Health, in press.
    6. Shinoda, Y., Sadakata, T., and Furuichi, T. Animal Models of Autism Spectrum Disorder (ASD): A Synaptic-level Approach to Autistic-like Behavior in Mice. Exp. Anim. 62(2), 71-78, 2013
    7. Okamura-Oho, Y., Shimokawa, K., Nishimura, M., Takemoto, S., Sato, A., Furuichi, T., and Yokota, H. Broad integration of expression maps and co-expression networks compassing novel gene functions in the brain. Sci. Rep. 4:6969, 2014
    8. Sato, Y., Yoshikawa, F., Sadakata, T., Shinoda, Y., Koebis, M., and Furuichi, T. Age-dependent redistribution and hypersialylation of the central myelin paranodal loop membrane protein Opalin in the mouse brain. Neurosci. Lett. 581: 14-19, 2014.
    9. Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba, R., Sekine, Y., Sato, Y., Saruta, C., Ishizaki, Y., Yuzaki, M., Kojima, M., and Furuichi, T. Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum. PLoS ONE 9(6): e99524, 2014
    10. Tanabe, K., Yamazaki, H., Inaguma, Y., Asada, A., Kimura, T., Takahashi, J., Taoka, M., Ohshima T., Furuichi, T., Isobe, T., Nagata, K., Shirao, T., and Hisanaga, S. Phosphorylation of Drebrin by Cyclin-Dependent Kinase 5 and Its Role in Neuronal Migration. PLoS ONE 9(3): e92291, 2014.
    11. Yoshikawa, F., Sato, Y., Tohyama, K., Akagi, T., Furuse, T., Sadakata, T., Tanaka, M., Shinoda, Y., Hashikawa, T., Itohara, S., Sano, Y., Ghandour, SM., Wakana, S., and Furuichi, T. Mammalian-specific central myelin protein Opalin is redundant for normal myelination: structural and behavioral assessments. PLoS ONE 11(11): e0166732, 2016
    12. Shinoda, Y., Ishii, C., Fukazawa, Y., Sadakata, T., Ishii, Y., Sano, Y., Iwasato, T., Itohara, S., and Furuichi, T. CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3–CA1 synapses in adult hippocampus. Scientific Rep. 6:31540, 2016
    13. Shinoda, Y., Nakajima, Y., Iguchi, H., Tatsumi, S., Kitaoka, M., Nakajima, M., Takahashi, T., Fujiwara, M., and Furuichi, T. Galacto-N-biose is neuroprotective against glutamate-induced excitotoxicity in vitro. Eur. J. Pharmacol. 791: 711-717, 2016
    14. Nakajima, Y., Iguchi, H., Kamisuki, S., Sugawara, F., Furuichi, T., and Shinoda, Y. Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. J. Toxicol. Sci., 41:311-319, 2016
    15. Hosono, M., Shinoda, Y., Hirano, T., Ishizaki, Y., Furuichi, T., and Sadakata, T. Interaction of Ca2+-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain. Neurosci. Lett. 617: 232–235, 2016
  • Takeshi Nakamura
    1. Nakamura T, Yasuda S, Nagai H, Koinuma S, Morishita S, Goto A, Kinashi T, Wada N. Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase. Genes Cells. 2013 Nov;18(11):1020-31.
    2. Fujita A, Koinuma S, Yasuda S, Nagai H, Kamiguchi H, Wada N, Nakamura T. GTP Hhdrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70. PLoS One. 2013 8, e79689.
    3. Vance P Lemmon, Adam R Ferguson, Phillip G Popovich, Xiao-Ming Xu, Diane M Snow, Michio Igarashi, Christine E Beatle, and John L Bixby. 2014. Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments. J. Neurotrauma 31, 1354-1361.
    4. Toshinori Morisaku, Yuhei Wada, Takeshi Nakamura, and Hiroharu Yui. 2017. Role of actin filaments and microtubules on the viscoelastic properties of the pklasma membrane in a fibroblast cell studied with the laser-induced surface deformation microscope. Analyst. in press.
  • Yoshikazu Higami
    1. Matsuo T, Miyata Y, Sagara Y, Higami Y, Tobu S, Matsuo M, Noguchi M, Shimokawa I, Kanetake H, Sakai H. Renoprotective effects of telmisartan after unilateral renal ablation in rats. Int J Nephrol Renovasc Dis. 2013 Oct 10;6:207-14.
    2. Okita N, Yoshimura M, Watanabe K, Minato S, Kudo Y, Higami Y, Tanuma S. CHK1 cleavage in programmed cell death is intricately regulated by both caspase and non-caspase family proteases. Biochim Biophys Acta. 2013 Jan;1830(1):2204-13.
    3. Chujo Y, Fujii N, Okita N, Konishi T, Narita T, Yamada A, Haruyama Y, Tashiro K, Chiba T, Shimokawa I, Higami Y. Caloric restriction-associated remodeling of rat white adipose tissue: effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration. Age (Dordr). 2013 Aug;35(4):1143-56
    4. Miyano K, Sudo Y, Yokoyama A, Hisaoka-Nakashima K, Morioka N, Takebayashi M, Nakata Y, Higami Y, Uezono Y. History of the G Protein-Coupled Receptor (GPCR) Assays From Traditional to a State-of-the-Art Biosensor Assay. J Pharmacol Sci. 126(4):302-9, 2014
    5. Hatachi G, Tsuchiya T, Miyazaki T, Matsumoto K, Yamasaki N, Okita N, Nanashima A, Higami Y, Nagayasu T. The poly(adenosine diphosphate-ribose) polymerase inhibitor PJ34 reduces pulmonary ischemia-reperfusion injury in rats. Transplantation. 98(6):618-24, 2014
    6. Okita N, Ishikawa N, Mizunoe Y, Oku M, Nagai W, Suzuki Y, Matsushima S, Mikami K, Okado H, Sasaki T, Higami Y. Inhibitory effect of p53 on mitochondrial content and function during adipogenesis. Biochem Biophys Res Commun. 446(1):91-7, 2014
    7. Terawaki K, Sawada Y, Kashiwase Y, Hashimoto H, Yoshimura M, Suzuki M, Miyano K, Sudo Y, Shiraishi S, Higami Y, Yanagihara K, Kase Y, Ueta Y, Uezono Y. New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line. Am J Physiol Endocrinol Metab. 306(4):E373-87, 2014
    8. Okita N, Tsuchiya T, Fukushima M, Itakura K, Yuguchi K, Narita T, Hashizume Y, Sudo Y, Chiba T, Shimokawa I, Higami Y. Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats. Exp Gerontol. 63:59-66, 2015
  • Ryusin Mizuta
    1. Arai, T., Koyama, R., Yuasa, M., Kitamura, D., Mizuta, R. Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose. BIOMEDICAL RESEARCH-TOKYO 35 (6): 389-395, (2014).
    2. Koyama, R., Arai, T., Kijima, M., Yuasa, M., Kitamura, D., Mizuta, R. Differential usage of DNase γ and DNase 1 to induce DNA degradation of dead cells in vivo. in preparation
    3. Koyama, R., Arai, T., Kijima, M., Sato, S., Miura, S., Yuasa, M., Kitamura, D., and Mizuta, R. DNase  DNase I and caspase-activated DNase cooperate to degrade dead cells. Genes to Cells 21, 1150–1163 (2016).
    4. Koyama, R. and Mizuta, R. Acrolein scavengers, cysteamine and N-benzylhydroxylamine, reduces the mouse liver damage after acetaminophen overdose. J. Vet. Med. Sci. 78, 1903–1905 (2016).
  • Naoko Ohtani
    1. Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge R-M, Jan Vijg J, Van Steeg H, Dollé MET, Hoeijmakers JHJ, de Bruin A, Hara E, Campisi J. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell, 31, 722-33 (2014).
    2. Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, Nakanishi M. Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction. Molecular Cell, 55, 1–12 (2014).
    3. Imai Y, Takahashi A, Hanyuu A, Hori S, Sato S, Naka K, Hirao A, Ohtani N, Hara E. Crosstalk between the RB-pathway and AKT signaling forms a Quiescence-Senescence switch. Cell Reports, 7, 194-207 (2014).
    4. Tze Mun Loo, Fumitaka Kamachi, Yoshihiro Watanabe, Shin Yoshimoto Hiroaki Kanda, Yuriko Arai, Yaeko Nakajima-Takagi, Atsushi Iwama, Tomoaki Koga, Yukihiko Sugimoto, Takayuki Ozawa, Masaru Nakamura, Miho Kumagai, Koichi Watashi, Makoto M Taketo, Tomohiro Aoki10, Shuh Narumiya, Masanobu Oshima, Makoto Arita, Eiji Hara and Naoko Ohtani. Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity. Cancer Discovery, in press, 2017.