久保研究室Kubo Lab.

久保 允人 教授Masato Kubo
久保研究室Kubo Lab.
研究分野Research Area
免疫学、アレルギー学Immunology, Allergolgy
研究テーマResearch theme



Masato Kubo Professor

Labo’s Website

Kubo Lab.
Research Category
Division of Molecular Pathology
Research theme
Identification of TFH cells in antibody responses to influenza virus vaccination.
The role of TFH cells in IgE responses during allergy.
The role of TH2 cells in allergic inflammatory responses.
The mechanisms by which immunological memory is established.
Identification of the epigenetic landscape in cytokine gene expression.
The role of innate immune cells (e.g., mast cells, basophils, innate lymphoid cells) in inflammatory responses.
In vivo imaging of the cytokine network in immune responses.

Helper T cells play central effector and regulatory roles in immunological surveillance, and disruption of these functions can lead to various immunological disorders. After maturation and programming, naive CD4+ T cells migrate into the periphery. Immune responses to invading pathogens are initiated when antigen-presenting cells present pathogen-derived peptides to naive CD4+ T cells, which are activated to undergo differentiation into several subsets of helper T cells that can be discriminated on the basis of their cytokine secretion profiles. T helper (TH) 1 cells secrete interleukin (IL)-2, IFN-γ and TNF-α in immune responses against intracellular pathogens and viruses. TH2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13 mainly against extracellular pathogens, and are responsible for allergic immune responses. TH17 cells produce IL-17 and IL-22 and are associated with autoimmune tissue inflammation. Follicular helper T cells (TFH) are a recently identified helper T cell subset that mainly localize in B cell follicles and germinal centers of secondary lymphoid organs. TFH cells play a role in B cell activation by secreting cytokines such as IL-4 and IL-21. All of these helper T cell subsets can differentiate from common naive precursor cells and the differentiation process is controlled by the particular cytokine environment in which antigen recognition takes place. The overriding goal of our research is to understand the molecular mechanisms underlying helper T cell differentiation and the epigenetic regulation of cytokine gene expression during cell lineage commitment.